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PMID: 10779496 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Using GeneWise in the Drosophila annotation experiment.

Genome research ·Vol. 10 ·No. 4 ·2000-04-00 ·Pages 547-8

Birney E, Durbin R

Abstract

The GeneWise method for combining gene prediction and homology searches was applied to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions. Further investigation indicates that many of the incorrect gene predictions from GeneWise were due to transposons with valid protein-coding genes and the remaining cases are pseudogenes or possible annotation oversights.

MeSH Terms
Animals Computational Biology/methods,statistics & numerical data Databases, Factual Drosophila melanogaster/genetics Genes, Insect/genetics Genome Sequence Homology, Nucleic Acid Software
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Birney E
Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. [email protected]
Durbin R
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.10.4.547
Email
[email protected]
Published
2000-04-00
Pages
547-8
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC310858
Subset
IM
Grants
Wellcome Trust · United Kingdom
Corrections
CommentIn
PMID: 10779478
External Links
PubMed source DOI: 10.1101/gr.10.4.547 PMC Full Text View journal details
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