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PMID: 10781084 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasticity in the organization and sequences of human KIR/ILT gene families.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 9 ·2000-04-25 ·Pages 4778-83

Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J

Abstract

The approximately 1-Mb leukocyte receptor complex at 19q13.4 is a key polymorphic immunoregion containing all of the natural killer-receptor KIR and related ILT genes. When the organization of the leukocyte receptor complex was compared from two haplotypes, the gene content in the KIR region varied dramatically, with framework loci flanking regions of widely variable gene content. The ILT genes were more stable in number except for ILT6, which was present only in one haplotype. Analysis of Alu repeats and comparison of KIR gene sequences, which are over 90% identical, are consistent with a recent origin. KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands.

MeSH Terms
Alu Elements Chromosome Mapping Chromosomes, Human, Pair 19 DNA Primers Exons Genetic Variation Haplotypes Humans Killer Cells, Natural Microsatellite Repeats Multigene Family Polymerase Chain Reaction Receptors, Immunologic/genetics Receptors, KIR
Chemicals
DNA Primers Receptors, Immunologic Receptors, KIR
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wilson M J
Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom.
Torkar M
Haude A
Milne S
Jones T
Sheer D
Beck S
Trowsdale J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.080588597
Published
2000-04-25
Pages
4778-83
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC18309
Subset
IM
Grants
Cancer Research UK · A3585 · United Kingdom
External Links
PubMed source DOI: 10.1073/pnas.080588597 PMC Full Text View journal details
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