Home LiteratureArticle Details
PMID: 10782769 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy.

AJNR. American journal of neuroradiology ·Vol. 21 ·No. 4 ·2000-04-00 ·Pages 621-30

Capizzano AA, Schuff N, Amend DL, Tanabe JL, Norman D, Maudsley AA, Jagust W, Chui HC, Fein G, Segal MR, Weiner MW

Abstract

Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography. The aim of this study was to characterize, by means of MR imaging and 1H MR spectroscopy, the structural and metabolic brain changes that occur among patients with subcortical ischemic vascular dementia compared with those of elderly control volunteers and patients with Alzheimer's disease. Patients with dementia and lacunes (n = 11), cognitive impairment and lacunes (n = 14), and dementia without lacunes (n = 18) and healthy age-matched control volunteers (n = 20) underwent MR imaging and 1H MR spectroscopy. 1H MR spectroscopy data were coanalyzed with coregistered segmented MR images to account for atrophy and tissue composition. Compared with healthy control volunteers, patients with dementia and lacunes had 11.74% lower N-acetylaspartate/creatine ratios (NAA/Cr) (P = .007) and 10.25% lower N-acetylaspartate measurements (NAA) in the cerebral cortex (P = .03). In white matter, patients with dementia and lacunes showed a 10.56% NAA/Cr reduction (P = .01) and a 12.64% NAA reduction (P = .04) compared with control subjects. NAA in the frontal cortex was negatively correlated with the volume of white matter signal hyperintensity among patients with cognitive impairment and lacunes (P = .002). Patients with dementia, but not patients with dementia and lacunes, showed a 10.33% NAA/Cr decrease (P = .02) in the hippocampus compared with healthy control volunteers. Patients with dementia and lacunes have reduced NAA and NAA/Cr in both cortical and white matter regions. Cortical changes may result from cortical ischemia/infarction, retrograde or trans-synaptic injury (or both) secondary to subcortical neuronal loss, or concurrent Alzheimer's pathologic abnormalities. Cortical derangement may contribute to dementia among patients with subcortical infarction.

MeSH Terms
Aged Aspartic Acid/analogs & derivatives,metabolism Brain Ischemia/complications,diagnosis,metabolism Creatine/metabolism Dementia, Vascular/complications,diagnosis,metabolism Female Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male
Chemicals
Aspartic Acid N-acetylaspartate Creatine
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Capizzano A A
Department of Veterans Affairs Medical Center, Magnetic Resonance Spectroscopy Unit, San Francisco, CA 94121, USA.
Schuff N
Amend D L
Tanabe J L
Norman D
Maudsley A A
Jagust W
Chui H C
Fein G
Segal M R
Weiner M W
References (54)
54 references, click to expand
  1. Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
    Radiology. 1998 Apr;207(1):91-102 PMID: 9530304
  2. LACUNES: SMALL, DEEP CEREBRAL INFARCTS.
    Neurology. 1965 Aug;15:774-84 PMID: 14315302
  3. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.
    Magn Reson Med. 1998 Dec;40(6):822-31 PMID: 9840826
  4. Positron emission tomography in vascular dementia.
    J Neurol Sci. 1998 Jan 21;154(1):55-61 PMID: 9543322
  5. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading.
    Histopathology. 1981 Sep;5(5):549-64 PMID: 7286917
  6. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
    Neurology. 1984 Jul;34(7):939-44 PMID: 6610841
  7. 1H NMR chemical shift selective (CHESS) imaging.
    Phys Med Biol. 1985 Apr;30(4):341-4 PMID: 4001160
  8. Why do frontal lobe symptoms predominate in vascular dementia with lacunes?
    Neurology. 1986 Mar;36(3):340-5 PMID: 3951700
  9. Leuko-araiosis.
    Arch Neurol. 1987 Jan;44(1):21-3 PMID: 3800716
  10. White matter changes in dementia of Alzheimer's type. Biochemical and neuropathological correlates.
    Brain. 1988 Dec;111 ( Pt 6):1425-39 PMID: 3208064
  11. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain.
    Neurosci Biobehav Rev. 1989 Spring;13(1):23-31 PMID: 2671831
  12. Magnetic resonance imaging and the severity of dementia in older adults.
    Arch Gen Psychiatry. 1990 Jan;47(1):47-51 PMID: 2294855
  13. Effects of capsular or thalamic stroke on metabolism in the cortex and cerebellum: a positron tomography study.
    Stroke. 1990 Apr;21(4):519-24 PMID: 2326833
  14. Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter.
    Arch Neurol. 1991 Mar;48(3):293-8 PMID: 1705796
  15. Neuropathological stageing of Alzheimer-related changes.
    Acta Neuropathol. 1991;82(4):239-59 PMID: 1759558
  16. A quantitative MRI study of vascular dementia.
    Neurology. 1992 Jan;42(1):138-43 PMID: 1734295
  17. MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease.
    Neurology. 1992 Jan;42(1):183-8 PMID: 1734300
  18. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers.
    Neurology. 1992 Mar;42(3 Pt 1):473-80 PMID: 1549205
  19. Severity of vascular dementia is related to volume of metabolically impaired tissue.
    Arch Neurol. 1992 Sep;49(9):909-13 PMID: 1520079
  20. Spectroscopic imaging display and analysis.
    Magn Reson Imaging. 1992;10(3):471-85 PMID: 1406098
  21. Cortical metabolism in posterolateral thalamic stroke: PET study.
    Acta Neurol Scand. 1992 Sep;86(3):285-90 PMID: 1414249
  22. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop.
    Neurology. 1993 Feb;43(2):250-60 PMID: 8094895
  23. Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.
    Radiology. 1993 May;187(2):433-7 PMID: 8475286
  24. Frontal-subcortical circuits and human behavior.
    Arch Neurol. 1993 Aug;50(8):873-80 PMID: 8352676
  25. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
    Ann Neurol. 1994 Jul;36(1):40-7 PMID: 8024260
  26. Reduced phase encoding in spectroscopic imaging.
    Magn Reson Med. 1994 Jun;31(6):645-51 PMID: 8057817
  27. Vascular subcortical dementias: clinical aspects.
    Dementia. 1994 May-Aug;5(3-4):177-80 PMID: 8087175
  28. Transsynaptic reduction in N-acetyl-aspartate in cerebellar diaschisis: a proton MR spectroscopic imaging study.
    J Comput Assist Tomogr. 1994 Sep-Oct;18(5):697-704 PMID: 8089315
  29. Binswanger's disease--revisited.
    Neurology. 1995 Apr;45(4):626-33 PMID: 7723946
  30. Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease.
    Magn Reson Imaging. 1995;13(3):457-62 PMID: 7791555
  31. Central nervous system trans-synaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study.
    Magn Reson Med. 1995 May;33(5):595-600 PMID: 7596262
  32. Cortical abnormalities associated with subcortical lesions in vascular dementia. Clinical and position emission tomographic findings.
    Arch Neurol. 1995 Aug;52(8):773-80 PMID: 7639629
  33. Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain.
    Magn Reson Med. 1995 Jun;33(6):755-9 PMID: 7651110
  34. H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
    Radiology. 1995 Nov;197(2):517-23 PMID: 7480705
  35. Alzheimer disease and subcortical ischemic vascular dementia: evaluation by combining MR imaging segmentation and H-1 MR spectroscopic imaging.
    Radiology. 1996 Feb;198(2):537-45 PMID: 8596863
  36. Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease.
    Stroke. 1996 Mar;27(3):408-14 PMID: 8610304
  37. Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
    Arch Neurol. 1996 Feb;53(2):167-74 PMID: 8639067
  38. Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.
    Arch Neurol. 1996 Jul;53(7):678-80 PMID: 8929176
  39. Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation.
    Magn Reson Med. 1996 May;35(5):678-87 PMID: 8722819
  40. From UBOs to Binswanger's disease. Impact of magnetic resonance imaging on vascular dementia research.
    Stroke. 1996 Aug;27(8):1269-73 PMID: 8711785
  41. Quantitative 1H spectroscopic imaging of human brain at 4.1 T using image segmentation.
    Magn Reson Med. 1996 Jul;36(1):21-9 PMID: 8795016
  42. Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging.
    Neurology. 1996 Sep;47(3):696-704 PMID: 8797467
  43. Vascular dementia: perfusional and metabolic disturbances and effects of therapy.
    J Neural Transm Suppl. 1996;47:183-91 PMID: 8841965
  44. Evidence for chronic ischaemia in the pathogenesis of vascular dementia: from neuroPATH to neuroPET.
    Acta Neurol Belg. 1996 Sep;96(3):228-31 PMID: 8886109
  45. Temporal lobe epilepsy: correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography.
    Magn Reson Med. 1997 Jan;37(1):18-23 PMID: 8978628
  46. Tissue segmentation of the brain in Alzheimer disease.
    AJNR Am J Neuroradiol. 1997 Jan;18(1):115-23 PMID: 9010529
  47. Estimating NAA in cortical gray matter with applications for measuring changes due to aging.
    Magn Reson Med. 1997 Mar;37(3):372-7 PMID: 9055227
  48. Regional cerebral blood flow measurements in the clinical evaluation of demented patients.
    Dement Geriatr Cogn Disord. 1997 Mar-Apr;8(2):92-7 PMID: 9065321
  49. Quantitative magnetic resonance analysis in vascular dementia.
    J Neurol. 1997 Apr;244(4):246-51 PMID: 9112593
  50. Cerebral blood flow in single and multiple lacunar infarctions.
    Stroke. 1997 Jul;28(7):1458-60 PMID: 9227700
  51. 1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
    Stroke. 1997 Oct;28(10):1940-3 PMID: 9341699
  52. Classification, diagnosis and treatment of vascular dementia.
    Drugs Aging. 1997 Nov;11(5):361-73 PMID: 9359023
  53. Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study.
    Neurology. 1997 Dec;49(6):1513-21 PMID: 9409338
  54. Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and APO E4 medial temporal lobe dementias. The Oxford Project to Investigate Memory and Aging.
    Int Psychogeriatr. 1997;9 Suppl 1:191-222; discussion 247-52 PMID: 9447442
Article Info
Journal
AJNR. American journal of neuroradiology
Abbr.
AJNR Am J Neuroradiol
ISSN
0195-6108
Published
2000-04-00
Pages
621-30
Language
English
Region
United States
NLM ID
8003708
PMCID
PMC1945115
Subset
IM
Grants
NIA NIH HHS · P01 AG012435 · United States
NIA NIH HHS · R01 AG10897 · United States
NIA NIH HHS · P01 AG12435 · United States
Corrections
CommentIn
PMID: 10782768
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2