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PMID: 1079853 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

IgM-induced tumor cell cytotoxicity mediated by normal thymocytes.

The Journal of experimental medicine ·Vol. 142 ·No. 2 ·1975-08-01 ·Pages 542-7

Lamon EW, Whitten HD, Lidin B, Fudenberg HH

Abstract

In summary, we have found that IgM, from mice which have undergone regression of primary MSV tumors, will induce cytotoxicity against the appropriate target cells by normal splenocytes and normal thymocytes. The thymocyte-induced cytotoxicity i

MeSH Terms
Animals Antibodies Chromium Radioisotopes Cytotoxicity Tests, Immunologic Immunoglobulin M/metabolism Mice Mice, Inbred BALB C/blood,immunology Moloney murine leukemia virus/immunology T-Lymphocytes/immunology
Chemicals
Antibodies Chromium Radioisotopes Immunoglobulin M
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lamon E W
Whitten H D
Lidin B
Fudenberg H H
References (19)
19 references, click to expand
  1. Cytotoxic lymphocytes from rats depleted of thymus processed cells.
    Nat New Biol. 1971 Jul 21;232(29):80-2 PMID: 5285343
  2. Antitumour activity in vitro dependent on immune B lymphocytes.
    Nat New Biol. 1973 Aug 15;244(137):209-11 PMID: 4542206
  3. In vitro cytotoxicity by a nonthymus-processed lymphocyte population with specificity for a virally determined tumor cell surface antigen.
    J Exp Med. 1972 Nov 1;136(5):1072-9 PMID: 4117188
  4. The lymphocyte response to a primary viral neoplasm (MSV) through its entire course in BALB-c mice.
    Int J Cancer. 1972 Nov;10(3):581-8 PMID: 4128689
  5. The role of immunoglobulins in lymphocyte-mediated cell damage, in vitro. I. Comparison of the effects of target cell specific antibody and normal serum factors on cellular damage by immune and non-immune lymphocytes.
    Immunology. 1970 Mar;18(3):397-404 PMID: 4191812
  6. The humoral antibody response to a primary viral neoplasm (MSV) through its entire course in BALB-c mice.
    Int J Cancer. 1973 Nov 15;12(3):637-45 PMID: 4364795
  7. Antibody-induced destruction of colon antigen-coated chicken erythrocytes by normal human lymphocytes.
    Eur J Immunol. 1971 Aug;1(4):281-5 PMID: 4258130
  8. The immune response to primary Moloney sarcoma virus tumors in BALB-c mice: cellular and humoral activity of long-term regressors.
    Int J Cancer. 1974 Jan 15;13(1):91-104 PMID: 4594340
  9. Cell-mediated immune reaction against tumors induced by oncornaviruses. II. Nature of the effector cells in tumor-cell cytolysis.
    Int J Cancer. 1973 Mar 15;11(2):426-32 PMID: 4545387
  10. In vitro demonstration of complement-dependent cytotoxic antibodies to Moloney sarcoma cells.
    J Immunol. 1974 Jun;112(6):1987-96 PMID: 4825783
  11. The lymphocyte response to primary Moloney sarcoma virus tumors in BALB-c mice. Definition of the active subpopulations at different times after infection.
    J Exp Med. 1973 Jun 1;137(6):1472-93 PMID: 4709269
  12. Antibody-mediated target cell lysis by non-immune cells. Characterization of the antibody and effector cell populations.
    Eur J Immunol. 1972 Oct;2(5):419-24 PMID: 5084393
  13. Lack of distinctive surface antigen on cells transformed by murine sarcoma virus.
    J Exp Med. 1972 Aug 1;136(2):344-52 PMID: 5043415
  14. Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes.
    Science. 1972 Jan 14;175(4018):194-6 PMID: 5008439
  15. Studies on Murine Sarcoma Virus: antigenic characterization of Murine Sarcoma Virus induced tumor cells.
    Int J Cancer. 1969 Jul 15;4(4):465-79 PMID: 4899685
  16. Comparison of the allospecific and viral-specific immune responses to irradiated versus formaldehyde-fixed allogeneic Moloney lymphoma cells in CBA mice.
    Cancer Res. 1975 Apr;35(4):962-9 PMID: 1090367
  17. Antibody-dependent lymphocyte cytotoxicity in the murine sarcoma virus system: activity of IgM and IgG with specificity for MLV determined antigen(s).
    J Immunol. 1975 Apr;114(4):1171-6 PMID: 1117138
  18. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.
    Cell Immunol. 1970 Sep;1(3):300-15 PMID: 5523583
  19. Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas.
    Int J Cancer. 1969 Sep 15;4(5):587-600 PMID: 5349009
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.2.542
Published
1975-08-01
Pages
542-7
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189886
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.2.542 PMC Full Text View journal details
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