Lymphocyte signaling: Cbl sets the threshold for autoimmunity.

Current biology : CB ·Vol. 10 ·No. 9 ·2000-05-04 ·Pages R344-7

Rudd CE, Schneider H

Abstract

Cbl, a negative regulator of immune signaling, has recently been shown to act as a ubiquitin-protein ligase. Further, two new papers describing Cbl-b-deficient mice suggest that Cbl-b sets the threshold of signaling in T and B cells and prevents the development of autoimmunity.

MeSH Terms

Adaptor Proteins, Signal Transducing Animals Autoimmunity/immunology B-Lymphocytes/immunology CD28 Antigens/immunology Carrier Proteins/immunology Ligases/immunology Mice Phosphoproteins/immunology Proto-Oncogene Proteins/immunology Proto-Oncogene Proteins c-cbl Receptors, Antigen, T-Cell/immunology Signal Transduction/immunology T-Lymphocytes/immunology Ubiquitin-Protein Ligases

Chemicals

Adaptor Proteins, Signal Transducing CD28 Antigens Carrier Proteins Cblb protein, mouse Phosphoproteins Proto-Oncogene Proteins Receptors, Antigen, T-Cell Proto-Oncogene Proteins c-cbl Ubiquitin-Protein Ligases Ligases Cbl protein, mouse

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rudd C E

Division of Tumor Immunology, Department of Cancer Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, USA. [email protected]

Schneider H

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00463-2

[email protected]

Published

2000-05-04

Pages

R344-7

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00463-2 View journal details

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