Transcriptional regulation: Kamikaze activators.

Current biology : CB ·Vol. 10 ·No. 9 ·2000-05-04 ·Pages R341-3

Thomas D, Tyers M

Abstract

Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.

MeSH Terms

Animals DNA-Binding Proteins/metabolism Ligases/metabolism Microphthalmia-Associated Transcription Factor Peptide Hydrolases/metabolism Proteasome Endopeptidase Complex RNA Polymerase II/metabolism Trans-Activators/metabolism Transcription Factors/metabolism Transcriptional Activation Ubiquitin-Protein Ligases Ubiquitins/metabolism

Chemicals

DNA-Binding Proteins Microphthalmia-Associated Transcription Factor Trans-Activators Transcription Factors Ubiquitins Ubiquitin-Protein Ligases RNA Polymerase II Peptide Hydrolases Proteasome Endopeptidase Complex ATP dependent 26S protease Ligases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Thomas D

Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvettte, 91198, France. [email protected]

Tyers M

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00462-0

[email protected]

Published

2000-05-04

Pages

R341-3

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00462-0 View journal details

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