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PMID: 10801456 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The nucleolus: the magician's hat for cell cycle tricks.

Current opinion in cell biology ·Vol. 12 ·No. 3 ·2000-06-00 ·Pages 372-7

Visintin R, Amon A

Abstract

The nucleolus, for decades considered a ribosome factory and site for ribosomal RNA synthesis and processing, has recently acquired new fame. Analyses of proteins important for cell-cycle regulation have shown that this organelle is used to sequester proteins, thereby inhibiting their activity.

MeSH Terms

Animals Cell Cycle/physiology Cell Cycle Proteins/metabolism Cell Nucleolus/metabolism Fungal Proteins/genetics,metabolism Genes, Fungal Humans Meiosis/physiology Nuclear Proteins Protein Tyrosine Phosphatases Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-mdm2 Saccharomyces cerevisiae/cytology,genetics,metabolism Saccharomyces cerevisiae Proteins

Chemicals

CDC14 protein, S cerevisiae Cell Cycle Proteins Fungal Proteins Nuclear Proteins Proto-Oncogene Proteins Saccharomyces cerevisiae Proteins MDM2 protein, human Proto-Oncogene Proteins c-mdm2 Protein Tyrosine Phosphatases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Visintin R

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Amon A

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(00)00102-2

Published

2000-06-00

Pages

372-7

Language

English

Region

England

NLM ID

8913428

Subset

Grants

NIGMS NIH HHS · GM 56800 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1016/s0955-0674(00)00102-2 View journal details

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The nucleolus: the magician's hat for cell cycle tricks.

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