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PMID: 10816483 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium.

Infection and immunity ·Vol. 68 ·No. 6 ·2000-06-00 ·Pages 3344-8

McSorley SJ, Jenkins MK

Abstract

Resolution of infection with attenuated Salmonella is an active process that requires CD4(+) T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28(+) CD4(+) T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4(+) T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.

MeSH Terms
Animals Antibodies, Bacterial/blood B-Lymphocytes/immunology CD28 Antigens CD4-Positive T-Lymphocytes/immunology Disease Models, Animal Female Immunity, Cellular Mice Mice, Inbred BALB C Mice, Nude Salmonella typhimurium/immunology,pathogenicity T-Lymphocyte Subsets/immunology Typhoid Fever/immunology,mortality Typhoid-Paratyphoid Vaccines/immunology Virulence
Chemicals
Antibodies, Bacterial CD28 Antigens Typhoid-Paratyphoid Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McSorley S J
Department of Microbiology and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. [email protected]
Jenkins M K
References (43)
43 references, click to expand
  1. Paradoxes of immunity and immunosuppression in Salmonella infection.
    Adv Exp Med Biol. 1988;239:353-66 PMID: 3059774
  2. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue.
    J Immunol. 1999 Jun 1;162(11):6552-61 PMID: 10352271
  3. Protective immunity induced by porin in experimental mouse salmonellosis.
    Microbiol Immunol. 1989;33(9):699-708 PMID: 2555656
  4. Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.
    Immunology. 1990 Feb;69(2):184-9 PMID: 2106482
  5. Role of CD4+ T cells and T-independent mechanisms in acquired resistance to Salmonella typhimurium infection.
    J Immunol. 1990 Aug 15;145(4):1265-9 PMID: 1974274
  6. The role of the CD28 receptor during T cell responses to antigen.
    Annu Rev Immunol. 1993;11:191-212 PMID: 8386518
  7. Role of T cells, TNF alpha and IFN gamma in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro- Salmonella vaccines.
    Microb Pathog. 1992 Dec;13(6):477-91 PMID: 1363824
  8. Differential T cell costimulatory requirements in CD28-deficient mice.
    Science. 1993 Jul 30;261(5121):609-12 PMID: 7688139
  9. The role of T cells in IgG production; thymus-dependent antigens induce B cell memory in the absence of T cells.
    J Immunol. 1975 Jun;114(6):1665-9 PMID: 47875
  10. Genetically conferred defect in anti-Salmonella antibody formation renders CBA/N mice innately susceptible to Salmonella typhimurium infection.
    J Immunol. 1981 Apr;126(4):1368-72 PMID: 7009738
  11. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines.
    Nature. 1981 May 21;291(5812):238-9 PMID: 7015147
  12. Immunity to infection with Salmonella typhimurium: mouse-strain differences in vaccine- and serum-mediated protection.
    J Infect Dis. 1984 Sep;150(3):425-35 PMID: 6207248
  13. Adoptive transfer of murine host protection to salmonellosis with T-cell growth factor-dependent, Salmonella-specific T-cell lines.
    Infect Immun. 1985 Apr;48(1):40-3 PMID: 3872265
  14. Prevention of typhoid fever in Nepal with the Vi capsular polysaccharide of Salmonella typhi. A preliminary report.
    N Engl J Med. 1987 Oct 29;317(18):1101-4 PMID: 3657877
  15. Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice.
    Infect Immun. 1988 Feb;56(2):419-23 PMID: 3276625
  16. Transfer of murine host protection by using interleukin-2-dependent T-lymphocyte lines.
    Infect Immun. 1988 Aug;56(8):2189-92 PMID: 3294188
  17. Adoptive transfer of immunity to oral challenge with virulent salmonellae in innately susceptible BALB/c mice requires both immune serum and T cells.
    Infect Immun. 1993 Sep;61(9):3981-4 PMID: 8359920
  18. Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.
    J Exp Med. 1994 Jul 1;180(1):15-23 PMID: 8006579
  19. Role of T cell subsets in immunity against intracellular bacteria: experimental infections of knock-out mice with Listeria monocytogenes and Mycobacterium bovis BCG.
    Immunobiology. 1994 Oct;191(4-5):509-19 PMID: 7713565
  20. The regulation of immunity to Leishmania major.
    Annu Rev Immunol. 1995;13:151-77 PMID: 7612219
  21. Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid.
    Infect Immun. 1996 Jan;64(1):189-96 PMID: 8557339
  22. Macrophage-T cell interaction in murine salmonellosis: selective down-regulation of ICAM-1 and B7 molecules in infected macrophages and its probable role in cell-mediated immunity.
    Eur J Immunol. 1996 Mar;26(3):563-70 PMID: 8605922
  23. Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.
    J Immunol. 1996 May 1;156(9):3321-6 PMID: 8617956
  24. CD28 is required for germinal center formation.
    J Immunol. 1996 Jun 15;156(12):4576-81 PMID: 8648099
  25. Salmonellosis: host immune responses and bacterial virulence determinants.
    Annu Rev Immunol. 1996;14:533-61 PMID: 8717524
  26. Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunization.
    Vaccine. 1996 Apr;14(5):435-8 PMID: 8735556
  27. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
    Immunity. 1996 Sep;5(3):285-93 PMID: 8808683
  28. Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters.
    Infect Immun. 1997 Jan;65(1):171-8 PMID: 8975908
  29. CD28 costimulation promotes the production of Th2 cytokines.
    J Immunol. 1997 Jan 15;158(2):658-65 PMID: 8992981
  30. Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.
    Infect Immun. 1997 Feb;65(2):452-6 PMID: 9009296
  31. Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nu/nu) BALB/c mice.
    Infect Immun. 1997 Apr;65(4):1566-9 PMID: 9119506
  32. Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes.
    Infect Immun. 1997 Jun;65(6):2306-12 PMID: 9169768
  33. Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.
    J Immunol. 1997 Jul 15;159(2):591-8 PMID: 9218573
  34. IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.
    Curr Opin Immunol. 1999 Jun;11(3):346-51 PMID: 10375558
  35. Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
    Science. 1997 Aug 15;277(5328):949-52 PMID: 9252325
  36. Acquired immunity to an intracellular pathogen: immunologic recognition of L. monocytogenes-infected cells.
    Immunol Rev. 1997 Aug;158:137-46 PMID: 9314082
  37. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism.
    J Exp Med. 1998 Jan 19;187(2):225-36 PMID: 9432980
  38. Antibody-mediated protection against intracellular pathogens.
    Trends Microbiol. 1998 Mar;6(3):102-7 PMID: 9582935
  39. Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant.
    Infect Immun. 1998 Jul;66(7):3378-83 PMID: 9632608
  40. Immune responses in the absence of costimulation: viruses know the trick.
    J Immunol. 1998 Dec 1;161(11):5791-4 PMID: 9834052
  41. Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.
    Infect Immun. 1999 Feb;67(2):700-7 PMID: 9916080
  42. Protection and immune responses induced by attenuated Salmonella typhimurium UK-1 strains.
    Microb Pathog. 1999 Mar;26(3):121-30 PMID: 10089152
  43. Anti-mu treatment suppresses immunoglobulin light-chain gene expression and Peyer's patch development.
    Mol Immunol. 1989 Apr;26(4):351-8 PMID: 2497338
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.68.6.3344-3348.2000
Email
[email protected]
Published
2000-06-00
Pages
3344-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC97596
Subset
IM
Grants
NIAID NIH HHS · R01 AI039614 · United States
NIAID NIH HHS · R37 AI027998 · United States
NIAID NIH HHS · R01 AI027998 · United States
NIAID NIH HHS · AI27998 · United States
NIAID NIH HHS · AI39614 · United States
External Links
PubMed source DOI: 10.1128/IAI.68.6.3344-3348.2000 PMC Full Text View journal details
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