Home LiteratureArticle Details
PMID: 10816539 Published · ppublish English Journal Article

Detection of 23 immunogenic pneumococcal proteins using convalescent-phase serum.

Infection and immunity ·Vol. 68 ·No. 6 ·2000-06-00 ·Pages 3740-3

Zysk G, Bongaerts RJ, ten Thoren E, Bethe G, Hakenbeck R, Heinz HP

Abstract

A genomic expression library of Streptococcus pneumoniae was screened with a convalescent-phase serum for immunoreactive proteins. Six known and 17 unknown pneumococcal proteins were detected. Five of the known proteins were surface-located virulence factors, and eight of the unknown proteins were putative membrane proteins.

MeSH Terms
Antibodies, Bacterial/blood Antigens, Bacterial/isolation & purification Bacterial Proteins/immunology,isolation & purification Convalescence Membrane Proteins/immunology,isolation & purification Pneumococcal Infections/immunology Virulence
Chemicals
Antibodies, Bacterial Antigens, Bacterial Bacterial Proteins Membrane Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zysk G
Department of Medical Microbiology and Virology, University of Duesseldorf, Duesseldorf, Germany. [email protected]
Bongaerts R J
ten Thoren E
Bethe G
Hakenbeck R
Heinz H P
References (18)
18 references, click to expand
  1. Serum antibodies to pneumolysin in patients with pneumonia.
    J Clin Microbiol. 1988 Jan;26(1):96-100 PMID: 3343319
  2. Autoaggregation of Lactobacillus reuteri is mediated by a putative DEAD-box helicase.
    Mol Microbiol. 1999 Apr;32(2):427-36 PMID: 10231497
  3. Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis.
    J Bacteriol. 1992 Jan;174(2):601-9 PMID: 1729249
  4. Cloning, sequence, and footprint analysis of two promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.
    J Bacteriol. 1994 Feb;176(4):1141-9 PMID: 8106325
  5. Three highly homologous membrane-bound lipoproteins participate in oligopeptide transport by the Ami system of the gram-positive Streptococcus pneumoniae.
    J Mol Biol. 1994 Aug 5;241(1):44-58 PMID: 8051706
  6. Cloning and expression of the beta-N-acetylglucosaminidase gene from Streptococcus pneumoniae. Generation of truncated enzymes with modified aglycon specificity.
    J Biol Chem. 1995 Apr 14;270(15):8805-14 PMID: 7721787
  7. Competence pheromone, oligopeptide permease, and induction of competence in Streptococcus pneumoniae.
    Mol Microbiol. 1996 Aug;21(3):471-8 PMID: 8866471
  8. Molecular analysis of putative pneumococcal virulence proteins.
    Microb Drug Resist. 1997 Spring;3(1):1-10 PMID: 9109091
  9. Heat shock response of Streptococcus pneumoniae: identification of immunoreactive stress proteins.
    Microb Pathog. 1997 Jul;23(1):11-21 PMID: 9250776
  10. The biology of pneumococcal infection.
    Pediatr Res. 1997 Sep;42(3):253-8 PMID: 9284261
  11. SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component.
    Mol Microbiol. 1997 Sep;25(6):1113-24 PMID: 9350867
  12. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.
    Mol Microbiol. 1997 Sep;25(5):819-29 PMID: 9364908
  13. Molecular cloning, expression, and characterization of dnaK in Streptococcus pneumoniae.
    FEMS Microbiol Lett. 1998 Apr 15;161(2):217-24 PMID: 9570114
  14. Novel pneumococcal surface proteins: role in virulence and vaccine potential.
    Trends Microbiol. 1998 Mar;6(3):85-7; discussion 87-8 PMID: 9582927
  15. Deletion of the central proline-rich repeat domain results in altered antigenicity and lack of surface expression of the Streptococcus mutans P1 adhesin molecule.
    Infect Immun. 1998 Sep;66(9):4274-82 PMID: 9712778
  16. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.
    Microbiol Mol Biol Rev. 1999 Mar;63(1):174-229 PMID: 10066836
  17. Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae.
    Infect Immun. 1999 Apr;67(4):1683-7 PMID: 10085004
  18. PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type.
    Infect Immun. 1991 Jan;59(1):222-8 PMID: 1987036
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.68.6.3740-3743.2000
Email
[email protected]
Published
2000-06-00
Pages
3740-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC97670
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.68.6.3740-3743.2000 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2