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PMID: 10819531 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The genetics of inherited breast cancer.

Journal of mammary gland biology and neoplasia ·Vol. 3 ·No. 4 ·1998-10-00 ·Pages 365-76

Gayther SA, Pharoah PD, Ponder BA

Abstract

The isolation of BRCA1 and BRCA2 has greatly increased our understanding of the genetics of inherited breast and ovarian cancer although the functions of these genes are not yet fully understood. We will discuss the current state of knowledge about the function of BRCA1 and BRCA2 and summarize the cancer risks in women carrying a BRCA1 or BRCA2 mutation. We review the evidence for gene-gene and gene-environment interaction in modifying that risk, and discuss the contribution of BRCA1 and BRCA2 and other high penetrance genes to both inherited and sporadic breast cancer.

MeSH Terms
BRCA1 Protein/genetics BRCA2 Protein Breast Neoplasms/genetics Chromosome Mapping Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 17 Female Genes, BRCA1 Genetic Markers Genetic Predisposition to Disease Humans Neoplasm Proteins/genetics Ovarian Neoplasms/genetics Risk Factors Transcription Factors/genetics
Chemicals
BRCA1 Protein BRCA2 Protein Genetic Markers Neoplasm Proteins Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gayther S A
CRC Human Cancer Genetics Research Group, Addenbrooke's Hospital, Cambridge, United Kingdom. [email protected]
Pharoah P D
Ponder B A
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1018779830743
Email
[email protected]
Published
1998-10-00
Pages
365-76
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1018779830743 View journal details
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