Autoimmunity can benefit self-maintenance.

Immunology today ·Vol. 21 ·No. 6 ·2000-06-00 ·Pages 265-8

Schwartz M, Cohen IR

Abstract

Autoimmunity is usually considered only as a cause of disease; nevertheless, human T-cell repertoires are filled naturally with autoimmune lymphocytes. Here, we review evidence that autoimmune T cells can help heal damaged tissues, indicating that natural autoimmunity could also be a cause of health.

MeSH Terms

Animals Autoantigens/immunology Autoimmunity Central Nervous System/immunology,pathology Chemotaxis, Leukocyte Contusions/immunology,pathology Encephalomyelitis, Autoimmune, Experimental/immunology Humans Injections, Intraperitoneal Lymphocyte Activation Models, Immunological Myelin Basic Protein/immunology Myelin Sheath/immunology Neovascularization, Physiologic/immunology Nerve Crush Nerve Degeneration/immunology Optic Nerve Injuries/immunology,pathology Regeneration/immunology Spinal Cord Injuries/immunology,pathology T-Lymphocyte Subsets/immunology,transplantation Wound Healing/immunology

Chemicals

Autoantigens Myelin Basic Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schwartz M

Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Cohen I R

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/s0167-5699(00)01633-9

Published

2000-06-00

Pages

265-8

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/s0167-5699(00)01633-9

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