Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease.

The American journal of medicine ·Vol. 60 ·No. 1 ·1976-01-00 ·Pages 157-66

Siegal FP, Voss R, Al-Mondhiry H, Polliack A, Hansen JA, Siegal M, Good RA

Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

MeSH Terms

Aged B-Lymphocytes/immunology Binding Sites, Antibody Carcinoma, Squamous Cell/complications Cell Membrane/immunology Chromosome Aberrations Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Female Humans Immune Adherence Reaction Immunoglobulin Fc Fragments Leukemia/complications,genetics,immunology Lung Neoplasms/complications Lymphocyte Activation Phenotype Pleural Effusion/etiology T-Lymphocytes/immunology

Chemicals

Immunoglobulin Fc Fragments

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Siegal F P

Voss R

Al-Mondhiry H

Polliack A

Hansen J A

Siegal M

Good R A

Article Info

Journal

The American journal of medicine

Abbr.

Am J Med

ISSN

0002-9343

DOI

10.1016/0002-9343(76)90545-3

Published

1976-01-00

Pages

157-66

Language

English

Region

United States

NLM ID

0267200

Subset

External Links

PubMed source DOI: 10.1016/0002-9343(76)90545-3 View journal details

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Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease.

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