Effect of atropine on the decay of miniature end-plate currents at the frog neuromuscular junction.

British journal of pharmacology ·Vol. 56 ·No. 1 ·1976-01-00 ·Pages 111-3

Feltz A, Large WA

Abstract

1 The effect of atropine on the time constant of decay (tau) of miniature end-plate currents was investigated. 2. The atropine-induced shortening of tau was accompanied by a reduction in the voltage-sensitivity of tau. 3. This effect of atropine was reversible and dose-dependent, the voltage sensitivity being abolished with high concentrations of atropine (2.5 X 10(-5)M).

MeSH Terms

Animals Atropine/pharmacology In Vitro Techniques Membrane Potentials/drug effects Neuromuscular Junction/drug effects Rana esculenta

Chemicals

Atropine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Feltz A

Large W A

References (12)

12 references, click to expand

A quantitative description of end-plate currents.
J Physiol. 1972 May;223(1):173-97 PMID: 5046143
The effect of voltage on the time course of end-plate currents.
J Physiol. 1972 May;223(1):151-71 PMID: 4537943
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
J Physiol. 1973 Dec;235(3):655-91 PMID: 4543940
The characteristics of 'end-plate noise' produced by different depolarizing drugs.
J Physiol. 1973 May;230(3):707-17 PMID: 4717155
Analysis of sodium and potassium conductances in the procaine end-plate potential.
J Physiol. 1966 Apr;183(3):592-606 PMID: 5919558
The effect of atropine on the frog sartorius neuromuscular junction.
J Physiol. 1968 Mar;195(2):493-503 PMID: 5647334
Endplate currents are shortened by octanol: possible role of membrane lipid.
Life Sci. 1974 Jun 1;14(11):2277-83 PMID: 4211253
Miniature end-plate currents in voltage-clamped muscle fibre.
Nature. 1968 Apr 27;218(5139):363-5 PMID: 5649678
Effects of membrane potential, temperature and neostigmine on the conductance change caused by a quantum or acetylcholine at the toad neuromuscular junction.
J Physiol. 1975 Jan;244(2):385-407 PMID: 806678
Equilibrium potential for the postsynaptic response in the squid giant synapse.
J Gen Physiol. 1974 Nov;64(5):519-35 PMID: 4374500
Acetylcholine receptors.
Q Rev Biophys. 1974 Jul;7(3):283-399 PMID: 4449983
Different action of atropine and some analogues on the end-plate potentials and induced acetylcholine potentials.
Experientia. 1969 Jun 15;25(6):618-9 PMID: 5800125

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1976.tb06965.x

Published

1976-01-00

Pages

111-3

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1666763

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1976.tb06965.x PMC Full Text View journal details

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Effect of atropine on the decay of miniature end-plate currents at the frog neuromuscular junction.

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