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PMID: 10838567 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells.

Trends in biochemical sciences ·Vol. 25 ·No. 6 ·2000-06-00 ·Pages 277-83

Malik S, Roeder RG

Abstract

A novel multiprotein complex has recently been identified as a coactivator for transcriptional control of protein-encoding genes by RNA polymerase II in higher eukaryotic cells. This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits.

MeSH Terms
Animals Gene Expression Regulation, Enzymologic Humans Invertebrates/genetics Models, Biological Peptides/chemistry RNA Polymerase II/genetics Transcription, Genetic Transcriptional Activation Yeasts/genetics
Chemicals
Peptides RNA Polymerase II
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Malik S
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA. [email protected]
Roeder R G
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/s0968-0004(00)01596-6
Email
[email protected]
Published
2000-06-00
Pages
277-83
Language
English
Region
England
NLM ID
7610674
Subset
IM
External Links
PubMed source DOI: 10.1016/s0968-0004(00)01596-6 View journal details
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