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PMID: 1083890 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines.

The Journal of experimental medicine ·Vol. 143 ·No. 6 ·1976-06-01 ·Pages 1528-33

Ralph P, Moore MA, Nilsson K

Abstract

A human cell line established in culture from a histiocytic lymphoma patient synthesizes and secretes the monocyte-granulocyte specific enzyme lysozyme. 18 other human cell lines with characteristics of T-lymphocyte, B-lymphocyte, Burkitt's lymphoma, non-Burkitt's lymphoma, myeloma, and bone marrow epithelial cells were not associated with lysozyme. Among murine cell lines, lysozyme was produced by (a) three histiocytic lymphoma or macrophage lines, which mediate antibody-dependent phagocytosis and cytolysis; (b) myelomonocytic leukemia line which also secretes myeloid colony-stimulating factor; and (c) a spontaneous lymphoma and an Abelson leukemia virus-induced lymphoma. Lysozyme-negative lines include another Abelson lymphoma, myelomas, T lymphomas, and mastocytoma.

MeSH Terms
Cell Line Colony-Stimulating Factors/biosynthesis Lymphoma/enzymology Muramidase/biosynthesis
Chemicals
Colony-Stimulating Factors Muramidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ralph P
Moore M A
Nilsson K
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23 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.143.6.1528
Published
1976-06-01
Pages
1528-33
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190228
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.143.6.1528 PMC Full Text View journal details
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