Home LiteratureArticle Details
PMID: 1085331 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response.

The Journal of experimental medicine ·Vol. 144 ·No. 2 ·1976-08-01 ·Pages 519-32

Zinkernagel RM, Dunlop MB, Blanden RV, Doherty PC, Shreffler DC

Abstract

Lymphocytic choriomeningitis virus (LCMV) and ectromelia virus-specific T-cell-mediated cytotoxicity was assayed in various strain combinations using as targets peritoneal macrophages which have been shown to express Ia antigens. Virus-specific cytotoxicity was found only in H-2K- or D-region compatible combinations. I-region compatibility was not necessary nor alone sufficient for lysis. Six different I-region specificities had no obvious effect on the capacity to generate in vivo specific cytotoxicity (expressed in vitro) associated with Dd. Low LCMV-specific cytotoxic activity generated in DBA/2 mice was caused by the non-H-2 genetic background. This trait was inversely related to the infectious virus dose and recessive. Non-H-2 genes, possibly involved in controlling initial spread and multiplication of virus, seem to be, at least in the examples tested, more important in determining virus-specific cytotoxic T-cell activity in spleens than are Ir genes coded in H-2.

MeSH Terms
Animals Antigens, Viral Chromosome Mapping Cytotoxicity Tests, Immunologic Genes Genes, Recessive Genetic Linkage Histocompatibility Antigens Immunity, Cellular Isoantigens Lymphocytic choriomeningitis virus/immunology Macrophages/immunology Mice Mice, Inbred Strains T-Lymphocytes/immunology Vaccinia virus/immunology
Chemicals
Antigens, Viral Histocompatibility Antigens Isoantigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zinkernagel R M
Dunlop M B
Blanden R V
Doherty P C
Shreffler D C
References (31)
31 references, click to expand
  1. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
    Nature. 1974 Apr 19;248(5450):701-2 PMID: 4133807
  2. Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.
    J Exp Med. 1974 Dec 1;140(6):1660-75 PMID: 4139235
  3. Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis.
    J Immunol. 1974 Apr;112(4):1548-52 PMID: 4592605
  4. The presence of I-region-associated antigens on B cells in molecules distinct from immunoglobulin and H-2K and H-2D.
    Proc Natl Acad Sci U S A. 1974 Dec;71(12):5014-6 PMID: 4140515
  5. Histocompatibility-linked immune response genes.
    Science. 1972 Jan 21;175(4019):273-9 PMID: 4109878
  6. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.
    Adv Immunol. 1974;18:67-132 PMID: 4151339
  7. Genetic control of the immune response: the effect of non-H-2 linked genes on antibody production.
    J Immunol. 1974 Apr;112(4):1329-36 PMID: 4360861
  8. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.
    Adv Immunol. 1975;20:125-95 PMID: 47219
  9. H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.
    J Exp Med. 1975 Feb 1;141(2):502-7 PMID: 123002
  10. Cell-mediated cytotoxicity against ectromelia virus-infected target cells. I. Specificity and kinetics.
    Eur J Immunol. 1974 Feb;4(2):63-7 PMID: 4211857
  11. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.
    Transplant Rev. 1976;29:89-124 PMID: 58463
  12. Lymphocytic choriomeningitis. Pathogenesis.
    Prog Med Virol. 1974;18(0):94-110 PMID: 4608239
  13. A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection.
    J Exp Med. 1976 Feb 1;143(2):450-5 PMID: 55454
  14. Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.
    J Exp Med. 1975 Oct 1;142(4):989-97 PMID: 51901
  15. T-cell-mediated immunopathology in viral infections.
    Transplant Rev. 1974;19(0):89-120 PMID: 4601807
  16. Cytotoxic thymus-derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis.
    J Exp Med. 1973 Nov 1;138(5):1266-9 PMID: 4542807
  17. Characteristics of the interaction in vitro between cytotoxic thymus-derived lymphocytes and target monolayers infected with lymphocytic choriomeningitis virus.
    Scand J Immunol. 1974;3(3):287-94 PMID: 4546752
  18. H-2 dependence of co-operation between T and B cells in vivo.
    J Immunol. 1972 Nov;109(5):940-3 PMID: 4538719
  19. On the control between cell-mediated, IgM and IgG immunity.
    Cell Immunol. 1974 Aug;13(2):171-95 PMID: 4451975
  20. Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection.
    J Exp Med. 1973 May 1;137(5):1201-12 PMID: 4702099
  21. Studies on cell-mediated immunity to lymphocytic choriomeningitis virus in mice.
    J Exp Med. 1973 Jun 1;137(6):1511-25 PMID: 4709270
  22. Variations in the responses of C57BL-10J and A-J mice to sheep red blood cells.
    J Exp Med. 1972 Nov 1;136(5):1063-71 PMID: 5082670
  23. Tissue injury in lymphocytic choriomeningitis viral infection: virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells.
    Virology. 1970 Dec;42(4):805-13 PMID: 4992354
  24. Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.
    J Immunol. 1975 Feb;114(2 pt 2):898-905 PMID: 1089721
  25. Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.
    J Exp Med. 1975 Jan 1;141(1):263-8 PMID: 1090698
  26. Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex.
    Nature. 1975 Mar 20;254(5497):269-70 PMID: 1078719
  27. Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus.
    Nature. 1975 Jun 12;255(5509):552-4 PMID: 1079922
  28. H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.
    Proc Natl Acad Sci U S A. 1975 Dec;72(12):5095-8 PMID: 1082137
  29. H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.
    J Exp Med. 1976 Feb 1;143(2):437-43 PMID: 1082490
  30. Inhibition of tumor angiogenesis mediated by cartilage.
    J Exp Med. 1975 Feb 1;141(2):427-39 PMID: 1113064
  31. The nature of the antigenic determinant in a genetic control of the antibody response.
    J Exp Med. 1969 Sep 1;130(3):493-504 PMID: 5807278
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.144.2.519
Published
1976-08-01
Pages
519-32
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190371
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.144.2.519 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2