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PMID: 10858254 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.

Infection and immunity ·Vol. 68 ·No. 7 ·2000-07-00 ·Pages 4331-4

Pearson JP, Feldman M, Iglewski BH, Prince A

Abstract

Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.

MeSH Terms
Animals Animals, Newborn Bacterial Proteins/genetics,physiology Disease Models, Animal Genes, Bacterial Ligases Mice Mice, Inbred BALB C Mutation Pneumonia, Bacterial/etiology,microbiology,pathology Pseudomonas Infections/etiology,microbiology,pathology Pseudomonas aeruginosa/genetics,pathogenicity,physiology Signal Transduction Transcription Factors/genetics,physiology Virulence/genetics
Chemicals
Bacterial Proteins LasI protein, Pseudomonas aeruginosa Transcription Factors Ligases RHLI protein, Pseudomonas aeruginosa
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pearson J P
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
Feldman M
Iglewski B H
Prince A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.68.7.4331-4334.2000
Published
2000-07-00
Pages
4331-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC101761
Subset
IM
Grants
NIDDK NIH HHS · R01 DK039693 · United States
NIDDK NIH HHS · R56 DK039693 · United States
NIAID NIH HHS · 5-T32 AI07362 · United States
NIAID NIH HHS · T32 AI007362 · United States
PHS HHS · A133713 · United States
NIDDK NIH HHS · DK39693 · United States
External Links
PubMed source DOI: 10.1128/IAI.68.7.4331-4334.2000 PMC Full Text View journal details
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