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PMID: 1086317 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 117 ·No. 4 ·1976-10-00 ·Pages 1079-84

Luderer AA, Maurer PH, Woodland RT

Abstract

In inbred rats, the antibody response to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n (T-G-A-Gly)n is under the control of two independently assorting loci; (co) dominant, Ag-B-linked Ir-(T-G-A-Gly) I, controlling qualitative responsivenss, and a non-Ag-B-linked modifier locus termed Ir-(T-G-A-Gly) II, controlling the level of antibody produced. The antibody response to (T-G-A-Gly)n was solely IgG and the level of antibody produced was dependent upon Ir-(T-G-A-Gly) II for phenotypic response type.

MeSH Terms

Adjuvants, Immunologic/pharmacology Alanine/immunology Amino Acid Sequence Animals Antibody Formation Binding Sites, Antibody Chromosome Mapping Crosses, Genetic Glutamine/immunology Glycine/immunology Hybridization, Genetic Mycobacterium/immunology Peptides/immunology Rats Rats, Inbred BN Rats, Inbred BUF Rats, Inbred F344 Rats, Inbred Lew Species Specificity Tyrosine/immunology

Chemicals

Adjuvants, Immunologic Peptides Glutamine Tyrosine Alanine Glycine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Luderer A A

Maurer P H

Woodland R T

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1976-10-00

Pages

1079-84

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

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Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses.

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