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PMID: 1087024 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Role of antigenic structure in cell to cell cooperation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 4184-6

Schwartz M, Hooghe RJ, Mozes E, Sela M

Abstract

Two synthetic polypeptides which differ only in the order of amino acids in their NH2-terminal side chains, namely, (Tyr-Tyr-Glu-Glu)-poly(DLAla)- -poly(LLys) and (Tyr-Glu-Try-Glu)-poly(DLAla)- -poly(LLys), were found to be under different genetic control. By three different in vivo systems for thymus-derived cell depletion, it was demonstrated that (Tyr-Tyr-Glu-Glu)-poly(DLAla)- -poly(LLys), which represents the random poly(Tyr,Glu)-poly(DLAla)- -poly(Lys) in the pattern of immune responses and in the quality of antibodies they elicit, is thymus-dependent whereas (Tyr-Glu-Tyr-Glu)-poly(DLAla)-poly(LLys) does not require thymus-derived cell help for efficient antibody production. Therefore, the two ordered polypeptides which are similar chemically differ in parameters, not yet determined, which affect their capability to trigger bone marrow-derived cells.

MeSH Terms
Amino Acid Sequence Animals Antibody Formation Antigens B-Lymphocytes/immunology Mice Mice, Inbred Strains Peptides/immunology Spleen/immunology Structure-Activity Relationship T-Lymphocytes/immunology
Chemicals
Antigens Peptides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schwartz M
Hooghe R J
Mozes E
Sela M
References (24)
24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.4184
Published
1976-11-00
Pages
4184-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431377
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.4184 PMC Full Text View journal details
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