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PMID: 1087328 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Spontaneous redistribution of surface immunoglobulin in the motile B lymphocyte.

The Journal of experimental medicine ·Vol. 144 ·No. 6 ·1976-12-01 ·Pages 1683-8

Schreiner GF, Braun J, Unanue ER

Abstract

This paper reports that B cells undergoing translatory motion spontaneously segregate their surface Ig to one portion of their plasma membrane. The spontaneous redistribution of surface Ig was found to be: (a) selective, concanavalin A-dependent on translatory motion and energy metabolism. Abundant B cells undergoing motility were found after cultures in lipopolysaccharide or trypsin, or after brief exposure to cholinergic drugs.

MeSH Terms
Animals B-Lymphocytes/immunology,physiology,ultrastructure Carbachol/pharmacology Cell Movement/drug effects Colchicine/pharmacology Cytoplasm/metabolism Histocompatibility Antigens Lipopolysaccharides/pharmacology Lymphocyte Activation Membrane Proteins/metabolism Mice Receptors, Antigen, B-Cell/metabolism Receptors, Concanavalin A/metabolism Trypsin
Chemicals
Histocompatibility Antigens Lipopolysaccharides Membrane Proteins Receptors, Antigen, B-Cell Receptors, Concanavalin A Carbachol Trypsin Colchicine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schreiner G F
Braun J
Unanue E R
References (11)
11 references, click to expand
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    Proc Natl Acad Sci U S A. 1973 May;70(5):1442-6 PMID: 4514314
  7. The modulation of spontaneous and anti-Ig-stimulated motility of lymphocytes by cyclic nucleotides and adrenergic and cholinergic agents.
    J Immunol. 1975 Feb;114(2 pt 2):802-8 PMID: 163280
  8. Factors affecting the redistribution of surface-bound concanavalin A on human polymorphonuclear leukocytes.
    J Cell Biol. 1974 Aug;62(2):351-65 PMID: 4426911
  9. Ultrastructural distribution and redistribution of alloantigens and concanavalin A receptors on the surface of mouse lymphocytes.
    Eur J Immunol. 1974 Feb;4(2):130-7 PMID: 4855301
  10. Calcium-sensitive modulation of Ig capping: evidence supporting a cytoplasmic control of ligand-receptor complexes.
    J Exp Med. 1976 Jan 1;143(1):15-31 PMID: 811752
  11. Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures.
    J Cell Biol. 1975 Apr;65(1):123-46 PMID: 1092699
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.144.6.1683
Published
1976-12-01
Pages
1683-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190482
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.144.6.1683 PMC Full Text View journal details
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