Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

Amyloid Precursor Protein Secretases Amyloid beta-Peptides/chemistry,metabolism Amyloid beta-Protein Precursor/chemistry,genetics,metabolism Animals Aspartic Acid Endopeptidases Cells, Cultured Endopeptidases/metabolism Gene Deletion Membrane Proteins/chemistry,genetics,metabolism Mice Mice, Knockout Peptide Fragments/chemistry,metabolism Presenilin-1 Presenilin-2 Protein Processing, Post-Translational Protein Structure, Tertiary Receptor, Notch1 Receptors, Cell Surface Transcription Factors Transfection

Amyloid beta-Peptides Amyloid beta-Protein Precursor Membrane Proteins Notch1 protein, mouse Peptide Fragments Presenilin-1 Presenilin-2 Receptor, Notch1 Receptors, Cell Surface Transcription Factors Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases Bace1 protein, mouse