TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

Adaptor Proteins, Signal Transducing Amino Acid Sequence Biological Transport Carrier Proteins/genetics,metabolism Cell Membrane/metabolism Cloning, Molecular Cytosol/metabolism Enzyme Activation Gene Library Humans Interleukin-1/pharmacology JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase Kinases/metabolism Mitogen-Activated Protein Kinases/metabolism Models, Biological Molecular Sequence Data NF-kappa B/metabolism Protein Binding Proteins/metabolism Signal Transduction TNF Receptor-Associated Factor 6 Two-Hybrid System Techniques

Adaptor Proteins, Signal Transducing Carrier Proteins Interleukin-1 NF-kappa B Proteins TAB2 protein, human TNF Receptor-Associated Factor 6 JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases MAP Kinase Kinase Kinases MAP kinase kinase kinase 7