Home LiteratureArticle Details
PMID: 10885360 Published · ppublish English Letter Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Melanisation of Cryptococcus neoformans in human brain tissue.

Lancet (London, England) ·Vol. 355 ·No. 9220 ·2000-06-10 ·Pages 2049-50

Nosanchuk JD, Rosas AL, Lee SC, Casadevall A

Abstract

Melanin-specific reagents revealed melanin in cryptococcal cell walls from human brain tissue, and fungal-cell melanin "ghosts" were recovered from infected tissue. The results indicate that Cryptococcus neoformans melanises during human infection.

MeSH Terms
Amphotericin B/therapeutic use Animals Antifungal Agents/therapeutic use Brain/pathology Cryptococcosis/drug therapy,metabolism Cryptococcus neoformans/enzymology,isolation & purification,metabolism Dopamine Antagonists/therapeutic use Humans Melanins/biosynthesis Rodentia Trifluoperazine/therapeutic use
Chemicals
Antifungal Agents Dopamine Antagonists Melanins Trifluoperazine Amphotericin B
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nosanchuk J D
Rosas A L
Lee S C
Casadevall A
Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
0140-6736
DOI
10.1016/S0140-6736(00)02356-4
Published
2000-06-10
Pages
2049-50
Language
English
Region
England
NLM ID
2985213R
Subset
IM
Grants
NIAID NIH HHS · AI13342 · United States
NHLBI NIH HHS · HL59842 · United States
NIAID NIH HHS · R01-AI22774 · United States
External Links
PubMed source DOI: 10.1016/S0140-6736(00)02356-4 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2