Stepwise specification of lymphocyte developmental lineages.

Current opinion in genetics & development ·Vol. 10 ·No. 4 ·2000-08-00 ·Pages 370-9

Rothenberg EV

Abstract

B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.

MeSH Terms

Animals B-Lymphocytes/cytology Cell Differentiation Cell Lineage DNA-Binding Proteins/metabolism Hematopoietic Stem Cells/cytology Humans Membrane Proteins/physiology PAX5 Transcription Factor Proteins/metabolism Receptors, Notch T-Lymphocytes/cytology Thymus Gland/cytology Trans-Activators/metabolism Transcription Factors

Chemicals

DNA-Binding Proteins EBF1 protein, human Membrane Proteins PAX5 Transcription Factor PAX5 protein, human Proteins Receptors, Notch Trans-Activators Transcription Factors

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Rothenberg E V

Division of Biology, California Institute of Technology, Pasadena 91125, USA. [email protected]

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(00)00098-8

[email protected]

Published

2000-08-00

Pages

370-9

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(00)00098-8 View journal details

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