Studies on the mechanism of stimulation of the humoral response of murine spleen cultures by culture fluids from human monocytes.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 3 ·1975-03-00 ·Pages 1094-100

Wood DD, Cameron PM

Abstract

It has been demonstrated that media derived from cultures of human monocytes can stimulate the IgM and IgG anti-sheep erythrocyte response of normal or T cell-deficient murine splenocytes in vitro. This culture fluid also causes a slight stimulation in the rate of B cell division and in the number of antibody-secreting cells occurring in the absence of added antigen. The active factors, which are released from the monocytes during the first 2 days of culture, appear to affect the murine B cells throughout the culture period.

MeSH Terms

Animals Antibody Formation Antigens Cell Separation Cells, Cultured Concanavalin A Erythrocytes/immunology Hemolytic Plaque Technique Humans Immunoglobulin G Immunoglobulin M Lymphocyte Activation Lymphocytes/immunology Mice Mice, Inbred C57BL Monocytes/immunology Sheep/immunology Spleen/cytology T-Lymphocytes/immunology Thymidine/metabolism Tritium

Chemicals

Antigens Immunoglobulin G Immunoglobulin M Tritium Concanavalin A Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wood D D

Cameron P M

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-03-00

Pages

1094-100

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Studies on the mechanism of stimulation of the humoral response of murine spleen cultures by culture fluids from human monocytes.

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