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PMID: 10899310 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

STAM2, a new member of the STAM family, binding to the Janus kinases.

FEBS letters ·Vol. 477 ·No. 1-2 ·2000-07-14 ·Pages 55-61

Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K

Abstract

We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively.

MeSH Terms

Adaptor Proteins, Signal Transducing Animals Binding Sites Cell Line Cloning, Molecular DNA/biosynthesis Endosomal Sorting Complexes Required for Transport Gene Expression Profiling Genes, Dominant/genetics Genes, myc/genetics Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology Growth Substances/pharmacology Humans Interleukin-2/pharmacology Janus Kinase 2 Janus Kinase 3 Molecular Sequence Data Multigene Family/genetics Phosphoproteins/chemistry,genetics Phosphorylation/drug effects Phosphotyrosine/metabolism Protein Binding Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins Sequence Deletion/genetics Signal Transduction/drug effects Substrate Specificity Transcriptional Activation/drug effects src Homology Domains

Chemicals

Adaptor Proteins, Signal Transducing Endosomal Sorting Complexes Required for Transport Growth Substances Interleukin-2 Phosphoproteins Proto-Oncogene Proteins STAM protein, human STAM2 protein, human Phosphotyrosine Granulocyte-Macrophage Colony-Stimulating Factor DNA Protein-Tyrosine Kinases JAK2 protein, human JAK3 protein, human Janus Kinase 2 Janus Kinase 3

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Endo K

Department of Microbiology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai 980-8575, Japan.

Takeshita T

Kasai H

Sasaki Y

Tanaka N

Asao H

Kikuchi K

Yamada M

Chenb M

O'Shea J J

Sugamura K

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/s0014-5793(00)01760-9

Published

2000-07-14

Pages

55-61

Language

English

Region

England

NLM ID

0155157

Subset

Databases

GENBANK

AF042273

External Links

PubMed source DOI: 10.1016/s0014-5793(00)01760-9 View journal details

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STAM2, a new member of the STAM family, binding to the Janus kinases.

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