Home LiteratureArticle Details
PMID: 1091625 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Origin of the TEM-beta-lactamase gene found on plasmids.

Journal of bacteriology ·Vol. 122 ·No. 1 ·1975-04-00 ·Pages 250-6

Heffron F, Sublett R, Hedges RW, Jacob A, Falkow S

Abstract

A sequence of deoxyribonucleic acid of 2.7 times 10-6 to 3.3 times 10-6 daltons which includes the TEM beta-lactamase gene is present on the small plasmid RSF 1030 (R-Amp). This same sequence is present on plasmid derivatives that have received a translocation of deoxyribonucleic acid specifying the TEM beta-lactamase and is also present on naturally occurring plasmids of the F1, F11, N, X, O, I, C, and W incompatibility groups that do not specify ampicillin resistance or specify O-type beta-lactamases.

MeSH Terms
Ampicillin/pharmacology Base Sequence Centrifugation, Density Gradient DNA, Bacterial/analysis Escherichia coli/drug effects,enzymology Extrachromosomal Inheritance Genes Microscopy, Electron Molecular Weight Nucleic Acid Hybridization Penicillin G/pharmacology Penicillin Resistance Penicillinase/biosynthesis Thymine
Chemicals
DNA, Bacterial Ampicillin Penicillinase Penicillin G Thymine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Heffron F
Sublett R
Hedges R W
Jacob A
Falkow S
References (30)
30 references, click to expand
  1. EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. VII. TWO TYPES OF NATURALLY OCCURRING R FACTORS.
    J Bacteriol. 1964 Sep;88:716-26 PMID: 14208512
  2. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation.
    J Bacteriol. 1961 May;81:669-78 PMID: 13783344
  3. Transposition of ampicillin resistance from RP4 to other replicons.
    Mol Gen Genet. 1974;132(1):31-40 PMID: 4609125
  4. R-factor-mediated beta-lactamases that hydrolyze oxacillin: evidence for two distinct groups.
    J Bacteriol. 1974 Aug;119(2):351-6 PMID: 4605004
  5. Incompatibility groups and the classification of fi - resistance factors.
    J Bacteriol. 1972 Nov;112(2):666-75 PMID: 4628744
  6. Plasmids determining I pili constitute a compatibility complex.
    J Gen Microbiol. 1973 Jul;77(1):19-25 PMID: 4579438
  7. An I pilus-determining R factor with anomalous compatibility properties, mobilizing a gentamicin-resistance plasmid.
    J Gen Microbiol. 1973 Jul;77(1):11-7 PMID: 4579435
  8. Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors.
    J Mol Biol. 1973 Apr 5;75(2):235-55 PMID: 4580676
  9. R factors from Proteus morganii.
    J Gen Microbiol. 1973 Aug;77(2):249-59 PMID: 4584057
  10. Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility.
    J Bacteriol. 1974 Jan;117(1):56-62 PMID: 4587613
  11. The chromosomal integration of a -lactamase gene derived from the P-type R-factor RP1 in Escherichia coli.
    Genet Res. 1972 Oct;20(2):231-7 PMID: 4569692
  12. R factors from Proteus rettgeri.
    J Gen Microbiol. 1972 Oct;72(3):543-52 PMID: 4564689
  13. Insertion mutations in microorganisms.
    Biochimie. 1972;54(2):177-85 PMID: 4563933
  14. R factors conferring resistance to trimethoprim but not sulphonamides.
    J Gen Microbiol. 1972 Dec;73(3):573-5 PMID: 4571517
  15. Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate.
    Virology. 1972 Dec;50(3):883-98 PMID: 4565618
  16. Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae.
    J Gen Microbiol. 1972 Sep;72(2):349-55 PMID: 4562309
  17. Use of a single-strand specific nuclease for analysis of bacterial and plasmid deoxyribonucleic acid homo- and heteroduplexes.
    J Bacteriol. 1973 Sep;115(3):904-11 PMID: 4728274
  18. Compatibility groups among fi - R factors.
    Nature. 1971 Nov 26;234(5326):222-3 PMID: 5002028
  19. Genetics of the Enterobacteriaceae. C. Molecular relationships among members of the Enterobacteriaceae.
    Adv Genet. 1971;16:81-118 PMID: 4947113
  20. Properties of an R factor from Pseudomonas aeruginosa.
    J Bacteriol. 1971 Dec;108(3):1244-9 PMID: 4945193
  21. Beta-lactamase of R factors.
    J Bacteriol. 1968 Oct;96(4):1441-2 PMID: 4971890
  22. Circular R-factor molecules controlling penicillinase synthesis, replicating in Escherichia coli under either relaxed or stringent control.
    J Bacteriol. 1970 Oct;104(1):34-44 PMID: 4919751
  23. Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.
    Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66 PMID: 4894690
  24. Studies on Escherichia coli sex factors. I. Specific labeling of F'Lac DNA.
    J Mol Biol. 1968 Feb 28;32(1):15-23 PMID: 4868116
  25. R-factor gene expression gram-negative bacteria.
    J Gen Microbiol. 1969 Jan;55(1):109-20 PMID: 4888148
  26. Transduction of various R factors by phage P1 in Escherichia coli and by phage P22 in Salmonella typhimurium.
    J Bacteriol. 1968 Nov;96(5):1791-5 PMID: 4882025
  27. Polynucleotide sequence relationships among members of Enterobacteriaceae.
    J Bacteriol. 1969 May;98(2):637-50 PMID: 4891264
  28. Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae.
    Nature. 1965 Oct 16;208(5007):239-41 PMID: 5326330
  29. Polynucleotide sequence relationships among Ent plasmids and the relationship between Ent and other plasmids.
    J Bacteriol. 1975 Jan;121(1):234-8 PMID: 1090570
  30. Mutant drug resistant factors of high transmissibility.
    Nature. 1967 May 27;214(5091):885-7 PMID: 6054969
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.122.1.250-256.1975
Published
1975-04-00
Pages
250-6
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235664
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.122.1.250-256.1975 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2