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PMID: 10923674 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A new member of the acid-sensing ion channel family.

Neuroreport ·Vol. 11 ·No. 10 ·2000-07-14 ·Pages 2217-22

Akopian AN, Chen CC, Ding Y, Cesare P, Wood JN

Abstract

Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family of two-pass transmembrane segment protein subunits which form multimeric cation channels. Members of the ENaC-degenerin family are gated by stimuli as diverse as protons, peptides and mechanical distension. Here we describe a new member of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the central nervous system in an overlapping population of neurons that also express the ASIC subunit MDEG2. ASIC-4 which shows 44% identify with ASIC is developmentally regulated and expressed in a subset of sensory neurons as well as in the CNS. However, despite the strong homology with ASIC, the ASIC-4 transcript does not encode a proton gated cation channel.

MeSH Terms

Acid Sensing Ion Channels Amino Acid Sequence Animals COS Cells Cell Line Chlorocebus aethiops Cloning, Molecular Conserved Sequence Degenerin Sodium Channels Epithelial Sodium Channels Ganglia, Spinal/metabolism Gene Library Ion Channels/chemistry,genetics,physiology Membrane Potentials/physiology Membrane Proteins Molecular Sequence Data Nerve Tissue Proteins/chemistry,genetics,physiology Neurons/metabolism Patch-Clamp Techniques Protein Subunits Rats Recombinant Proteins/metabolism Sequence Alignment Sequence Homology, Amino Acid Sodium Channels/chemistry,genetics,physiology Spinal Cord/metabolism Transcription, Genetic Transfection

Chemicals

ASIC2 protein, human ASIC3 protein, human Acid Sensing Ion Channels Asic2 protein, rat Degenerin Sodium Channels Epithelial Sodium Channels Ion Channels Membrane Proteins Nerve Tissue Proteins Protein Subunits Recombinant Proteins Sodium Channels

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Akopian A N

Department of Biology, University College London, UK.

Chen C C

Ding Y

Cesare P

Wood J N

Article Info

Journal

Neuroreport

Abbr.

Neuroreport

ISSN

0959-4965

DOI

10.1097/00001756-200007140-00031

Published

2000-07-14

Pages

2217-22

Language

English

Region

England

NLM ID

9100935

Subset

External Links

PubMed source DOI: 10.1097/00001756-200007140-00031 View journal details

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