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PMID: 10924473 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density.

Genetics ·Vol. 155 ·No. 4 ·2000-08-00 ·Pages 1773-88

Leips J, Mackay TF

Abstract

The genetic architecture of variation in adult life span was examined for a population of recombinant inbred lines, each of which had been crossed to both inbred parental strains from which the lines were derived, after emergence from both high and low larval density. QTL affecting life span were mapped within each sex and larval density treatment by linkage to highly polymorphic roo-transposable element markers, using a composite interval mapping method. We detected a total of six QTL affecting life span; the additive effects and degrees of dominance for all were highly sex- and larval environment-specific. There were significant epistatic interactions between five of the life span QTL, the effects of which also differed according to genetic background, sex, and larval density. Five additional QTL were identified that contributed to differences among lines in their sensitivity to variation in larval density. Further fine-scale mapping is necessary to determine whether candidate genes within the regions to which the QTL map are actually responsible for the observed variation in life span.

MeSH Terms
Analysis of Variance Animals Breeding Chromosomes Crosses, Genetic Drosophila melanogaster/genetics,physiology Environment Epistasis, Genetic Female Genes, Dominant Genetic Markers Genetic Variation Genotype Heterozygote Homozygote Larva/anatomy & histology Life Expectancy Male Phenotype Quantitative Trait, Heritable Sex Factors Time Factors
Chemicals
Genetic Markers
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Leips J
Department of Genetics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA. [email protected]
Mackay T F
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/155.4.1773
Email
[email protected]
Published
2000-08-00
Pages
1773-88
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1461186
Subset
IM
Grants
NIGMS NIH HHS · GM18818-03 · United States
NIGMS NIH HHS · GM45146 · United States
NIGMS NIH HHS · GM45344 · United States
External Links
PubMed source DOI: 10.1093/genetics/155.4.1773 PMC Full Text View journal details
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