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PMID: 1092609 Published · ppublish English Comparative Study Journal Article

Effect of Corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes.

Immunology ·Vol. 28 ·No. 3 ·1975-03-00 ·Pages 431-42

Warr GW, James K

Abstract

Several strains of mice were injected with sheep erythrocytes (SRBC) using C. parvum as adjuvant. The adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order IgG2b greater than IgG2a and IgM greater than IgG1. In addition, these effects were shown to vary depending on the time of administration of C. parvum relative to antigen. C parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the antigen, SRBC. On the basis of the reported observations it is suggested that certain of the adjuvant effects of C. parvum require T-cell function.

MeSH Terms
Adjuvants, Immunologic Animals Antibody Formation Antibody-Producing Cells Corynebacterium/immunology Erythrocytes/immunology Hemolytic Plaque Technique Immunization Immunoglobulin G Immunoglobulin M Mice Mice, Inbred Strains/immunology Organ Size Propionibacterium acnes/immunology Sheep/immunology Spleen/immunology T-Lymphocytes Thymus Gland/immunology Time Factors
Chemicals
Adjuvants, Immunologic Immunoglobulin G Immunoglobulin M
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Warr G W
James K
References (21)
21 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1975-03-00
Pages
431-42
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445794
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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