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PMID: 1092612 Published · ppublish English Journal Article

T cell-dependent mediator in the immune response. III. The role of non-specific factor (NSF) in the in vitro immune response.

Immunology ·Vol. 28 ·No. 3 ·1975-03-00 ·Pages 497-507

Waldmann H

Abstract

Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.

MeSH Terms
Animals Antibodies Antibody Formation Antibody Specificity Antibody-Producing Cells Antigen-Antibody Reactions Antigens/analysis Carrier Proteins Cells, Cultured Erythrocytes/immunology Freund's Adjuvant Haptens Hemolytic Plaque Technique Immunity Immunization Mice Mice, Inbred CBA Protein Binding Sheep/immunology T-Lymphocytes/immunology
Chemicals
Antibodies Antigens Carrier Proteins Haptens Freund's Adjuvant
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Waldmann H
References (21)
21 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1975-03-00
Pages
497-507
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1445774
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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