The distribution of muramidase (lysozyme) in human tissues.

Journal of clinical pathology ·Vol. 28 ·No. 2 ·1975-02-00 ·Pages 124-32

Mason DY, Taylor CR

Abstract

The distribution of muramidase (lysozyme) in normal and pathological human tissues has been studied, using an immunohistological technique. The enzyme was demonstrated in a variety of healthy tissues, including serous salivary acinar cells, lactating mammary tissue, Paneth cells, renal tubular cells, myeloid cells (including eosinophils), and histiocytic cells. In pathological tissues the most striking positivity was encountered in reactive histiocytic cells in granulomatous conditions such as tuberculosis and Crohn's disease. The finding of this study are related to previous reports of the distribution of human and animal muramidase and the implications of patterns of muramidase staining in pathological histiocytes are briefly discussed.

MeSH Terms

Bone Marrow/enzymology Bone Marrow Cells Breast/enzymology Crohn Disease/enzymology Eosinophils/enzymology Histological Techniques Humans Immune Sera Immunologic Techniques Intestinal Mucosa/enzymology Kidney Tubules, Distal/enzymology Kidney Tubules, Proximal/enzymology Kupffer Cells/enzymology Lacrimal Apparatus/enzymology Lymph Nodes/enzymology Muramidase/metabolism Salivary Glands/enzymology Tuberculosis/enzymology

Chemicals

Immune Sera Muramidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mason D Y

Taylor C R

References (27)

27 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.28.2.124

Published

1975-02-00

Pages

124-32

Language

English

Region

England

NLM ID

0376601

PMCID

PMC475611

Subset

External Links

PubMed source DOI: 10.1136/jcp.28.2.124 PMC Full Text View journal details

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