Home LiteratureArticle Details

PMID: 1092760 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Pathogenesis of rabies in immunodeficient mice.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 6 ·1975-06-00 ·Pages 1761-5

Kaplan MM, Wiktor TJ, Koprowski H

Abstract

The HEP and ts2 strains of rabies virus inoculated intracerebrally into adult mice normally cause clinically inapparent infection. In the experiments described, this is converted into a lethal infection by immunosuppression with cyclophosphamide, which also prevented induction of immunity with vaccine. Lethal infection of HEP-inoculated mice was also observed in mice treated with antihymocytic serum, and in athymic (BALB/c-nu) nude mice.

MeSH Terms

Animals Antilymphocyte Serum/pharmacology Cyclophosphamide/pharmacology Fluorescent Antibody Technique Immune Sera Immunosuppression Therapy Mice Mice, Inbred BALB C Mice, Nude Neutralization Tests Rabbits/immunology Rabies/immunology Rabies Vaccines Rabies virus/immunology Thymus Gland/immunology Virus Replication

Chemicals

Antilymphocyte Serum Immune Sera Rabies Vaccines Cyclophosphamide

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kaplan M M

Wiktor T J

Koprowski H

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-06-00

Pages

1761-5

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

Analysis Services

Pathogenesis of rabies in immunodeficient mice.

Contact

WeChat Official Account