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PMID: 10931139 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis.

Clinical and experimental immunology ·Vol. 121 ·No. 2 ·2000-08-00 ·Pages 255-60

Bruunsgaard H, Skinhøj P, Pedersen AN, Schroll M, Pedersen BK

Abstract

Ageing is associated with increased inflammatory activity in the blood. The purpose of this study was to investigate if age-related increased plasma levels of TNF-alpha were associated with atherosclerosis in a cohort of 130 humans aged 81 years. The elderly cohort had increased circulating levels of TNF-alpha, C-reactive protein (CRP), total cholesterol (TC), low-density lipoproteins (LDL) and a low high-density lipoprotein (HDL)/TC ratio compared with a young control group (n = 44). The elderly cohort was divided by tertiles into three subgroups with low, intermediate, and high levels of TNF-alpha, respectively. In the group with high TNF-alpha concentrations a significantly larger proportion had clinical diagnoses of atherosclerosis. Furthermore, weak correlations were found between TNF-alpha on one hand and blood concentrations of triglycerides, leucocytes, CRP and a low HDL/TC ratio on the other which are known as risk factors of atherogenesis and thromboembolic complications. No correlations were found between TNF-alpha, TC, LDL, or the body mass index. In conclusion, the present study shows that in a cohort of 81-year-old humans, high levels of TNF-alpha in the blood were associated with a high prevalence of atherosclerosis.

MeSH Terms
Adult Aged Aged, 80 and over Aging/metabolism Arteriosclerosis/epidemiology,etiology Arteritis/blood C-Reactive Protein/analysis Cholesterol/blood Cohort Studies Disease Susceptibility Female Humans Leukocyte Count Male Triglycerides/blood Tumor Necrosis Factor-alpha/analysis,metabolism
Chemicals
Triglycerides Tumor Necrosis Factor-alpha C-Reactive Protein Cholesterol
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bruunsgaard H
Department of Infectious Diseases, H:S, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [email protected]
Skinhøj P
Pedersen A N
Schroll M
Pedersen B K
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1046/j.1365-2249.2000.01281.x
Email
[email protected]
Published
2000-08-00
Pages
255-60
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1905691
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2249.2000.01281.x PMC Full Text View journal details
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