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PMID: 1093137 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

On the statistical significance of primary structural features found in DNA-protein interaction sites.

Nucleic acids research ·Vol. 2 ·No. 3 ·1975-03-00 ·Pages 327-45

Dykes G, Bambara R, Marians K, Wu R

Abstract

Probabilities of occurrence for a number of the symmetries and other sequence regularities found in DNA-protein interaction site sequences have been calculated for segments of random DNA sequence. Results show that many of the symmetrical and repetitive features seen in these interaction sites are likely to have occured by chance. Other features are so unlikely to have occurred by chance that they are probably involved in the DNA-protein interaction processes.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Base Sequence Binding Sites DNA DNA-Directed RNA Polymerases/metabolism Deoxyribonucleotides/analysis Escherichia coli/metabolism Genes Mathematics Models, Biological Mutation Probability Protein Binding Protein Biosynthesis Proteins
Chemicals
Amino Acids Deoxyribonucleotides Proteins DNA DNA-Directed RNA Polymerases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dykes G
Bambara R
Marians K
Wu R
References (23)
23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/2.3.327
Published
1975-03-00
Pages
327-45
Language
English
Region
England
NLM ID
0411011
PMCID
PMC342839
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/2.3.327 PMC Full Text View journal details
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