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PMID: 1095680 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Termination of aquired and natural immunological tolerance with specific complexes.

The Journal of experimental medicine ·Vol. 142 ·No. 2 ·1975-08-01 ·Pages 312-20

Habicht GS, Chiller JM, Weigle WO

Abstract

It was possible to terminate the induced unresponsive state to bovine serum albumin (BSA) and the natural unresponsive state to autologous thyroglobulin in rabbits (RTg) by immunization with complexes composed of heterologous cross-reacting antibody and the tolerated antigens. The unresponsive state was terminated in rabbits made unresponsive by neonatal injections of BSA and then 3 mo later injected with complexes composed of BSA and guinea pig antihuman serum albumin. This termination was manifested by the presence of anti-BSA plaque-forming cells. Similarly, the natural unresponsive state was terminated in adult rabbits injected with complexes between RTg and guinea pig antibovine thyroglobulin (BTg) in that thyroid lesions and circulating anti-RTg were produced. The results can be best explained by the presence of unresponsive T cells and competent B cells, where the guinea pig gamma globulin (antibody) activates T cells specific for the guinea pig gamma globulin portion of the complexes and thus permits stimulation of B cells competent to the exposed determinants of the tolerated (BSA or RTg) portion of the complexes. The detailed mechanism for the activation of B cells in tolerant animals is discussed.

MeSH Terms
Animals Antibodies Antigen-Antibody Complex Cattle Cross Reactions Guinea Pigs Hemagglutination Tests Hemolytic Plaque Technique Humans Immune Tolerance Lymph Nodes/immunology Precipitin Tests Rabbits Serum Albumin/immunology Serum Albumin, Bovine/immunology Thyroglobulin/immunology Thyroid Gland/pathology
Chemicals
Antibodies Antigen-Antibody Complex Serum Albumin Serum Albumin, Bovine Thyroglobulin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Habicht G S
Chiller J M
Weigle W O
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25 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.2.312
Published
1975-08-01
Pages
312-20
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189899
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.2.312 PMC Full Text View journal details
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