Wnt/beta-catenin signaling.

Cytokine & growth factor reviews ·Vol. 11 ·No. 4 ·2000-12-00 ·Pages 273-82

Akiyama T

Abstract

The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers.

MeSH Terms

Amino Acid Sequence Animals Axin Protein Cytoskeletal Proteins/chemistry,genetics,physiology DNA-Binding Proteins/chemistry,genetics,physiology Embryonic and Fetal Development Genes, APC Humans Lymphoid Enhancer-Binding Factor 1 Molecular Sequence Data Mutation Neoplasms/etiology Proteins/physiology Proto-Oncogene Proteins/physiology Repressor Proteins Signal Transduction Trans-Activators Transcription Factors/chemistry,genetics,physiology Wnt Proteins Zebrafish Proteins beta Catenin

Chemicals

Axin Protein CTNNB1 protein, human Cytoskeletal Proteins DNA-Binding Proteins Lymphoid Enhancer-Binding Factor 1 Proteins Proto-Oncogene Proteins Repressor Proteins Trans-Activators Transcription Factors Wnt Proteins Zebrafish Proteins beta Catenin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Akiyama T

Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032, Tokyo, Japan. [email protected]

Article Info

Journal

Cytokine & growth factor reviews

Abbr.

Cytokine Growth Factor Rev

ISSN

1359-6101

DOI

10.1016/s1359-6101(00)00011-3

[email protected]

Published

2000-12-00

Pages

273-82

Language

English

Region

England

NLM ID

9612306

Subset

External Links

PubMed source DOI: 10.1016/s1359-6101(00)00011-3 View journal details

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