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PMID: 10973283 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Natural killer cells determine the outcome of B cell-mediated autoimmunity.

Nature immunology ·Vol. 1 ·No. 3 ·2000-09-00 ·Pages 245-51

Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG

Abstract

Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.

MeSH Terms
Amino Acid Sequence Animals Antibody Formation/immunology Autoantibodies/immunology Autoimmunity/immunology B-Lymphocytes/immunology Female Immunization Inbreeding Interferon-gamma/biosynthesis,immunology Interleukin-8/genetics,immunology Killer Cells, Natural/immunology Lymphocyte Activation/immunology Mice Mice, Inbred C57BL Molecular Sequence Data Myasthenia Gravis, Autoimmune, Experimental/immunology Receptors, Nicotinic/immunology T-Lymphocytes/immunology Torpedo Transforming Growth Factor beta/biosynthesis,immunology
Chemicals
Autoantibodies Interleukin-8 Receptors, Nicotinic Transforming Growth Factor beta Interferon-gamma
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Shi F D
Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Wang H B
Li H
Hong S
Taniguchi M
Link H
Van Kaer L
Ljunggren H G
Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2908
DOI
10.1038/79792
Published
2000-09-00
Pages
245-51
Language
English
Region
United States
NLM ID
100941354
Subset
IM
External Links
PubMed source DOI: 10.1038/79792 View journal details
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