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PMID: 1097509 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antagonism of B lymphocyte mitogenesis by anti-immunoglobulin antibody.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 115 ·No. 2 ·1975-08-00 ·Pages 323-6

Schrader JW

Abstract

Anti-mouse-immunoglobulin-antibodies (AMIg) were shown to suppress mitogenesis in B lymphocytes that were cultured with lipopolysaccharide, (LPS), or polymerized-flagellin, (POL). Preincubation of spleen cells with AMIg plus LPS has a greater suppressive effect on a subsequent mitogenic response to LPS than did preincubation with AMIg alone. Preincubation with LPS alone had, if anything, a slight enhancing effect. These experiments suggested that AMIg did not suppress mitogenesis by interference with the initial binding of the mitogen, but rather exerted a separated negative effect that occurred subsequent to, or in the process of, B cell-stimulation.

MeSH Terms
Animals Antibodies, Anti-Idiotypic B-Lymphocytes/immunology Cells, Cultured Escherichia coli/immunology Flagellin Goats/immunology Idoxuridine/metabolism Immune Sera Immunoglobulins Immunosuppression Therapy Iodine Radioisotopes Lipopolysaccharides Lymphocyte Activation Mice Mice, Inbred CBA Mice, Nude Mitosis Polysaccharides, Bacterial Salmonella/immunology Salmonella typhimurium/immunology Sheep/immunology Thymidine/metabolism Tritium
Chemicals
Antibodies, Anti-Idiotypic Immune Sera Immunoglobulins Iodine Radioisotopes Lipopolysaccharides Polysaccharides, Bacterial Tritium Flagellin Idoxuridine Thymidine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schrader J W
Article Info
Journal
Journal of immunology (Baltimore, Md. : 1950)
Abbr.
J Immunol
ISSN
0022-1767
Published
1975-08-00
Pages
323-6
Language
English
Region
United States
NLM ID
2985117R
Subset
IM
External Links
PubMed source View journal details
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