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PMID: 10995780 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Brain tissue responses to ischemia.

The Journal of clinical investigation ·Vol. 106 ·No. 6 ·2000-09-00 ·Pages 723-31

Lee JM, Grabb MC, Zipfel GJ, Choi DW

Abstract

暂无摘要

MeSH Terms
Apoptosis/drug effects Brain/drug effects,metabolism,pathology,physiopathology Brain Ischemia/metabolism,pathology,physiopathology,therapy Cytoprotection/drug effects Excitatory Amino Acid Antagonists/pharmacology Free Radicals/pharmacology Growth Substances/pharmacology Humans Inflammation/physiopathology Necrosis Neuroprotective Agents/pharmacology Neurotransmitter Agents/antagonists & inhibitors,pharmacology Signal Transduction/drug effects Zinc/antagonists & inhibitors,pharmacology
Chemicals
Excitatory Amino Acid Antagonists Free Radicals Growth Substances Neuroprotective Agents Neurotransmitter Agents Zinc
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lee J M
Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Grabb M C
Zipfel G J
Choi D W
References (49)
49 references, click to expand
  1. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice.
    Br J Pharmacol. 1998 Jun;124(4):756-62 PMID: 9690868
  2. A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.
    J Physiol. 1996 Dec 15;497 ( Pt 3):761-72 PMID: 9003561
  3. Protective responses in the ischemic myocardium.
    J Clin Invest. 2000 Oct;106(7):813-8 PMID: 11018066
  4. Cell death: the significance of apoptosis.
    Int Rev Cytol. 1980;68:251-306 PMID: 7014501
  5. The search for physiological substrates of MAP and SAP kinases in mammalian cells.
    Trends Cell Biol. 1997 Sep;7(9):353-61 PMID: 17708980
  6. A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor.
    Exp Neurol. 1992 Jan;115(1):163-6 PMID: 1728563
  7. Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?
    Eur J Pharmacol. 1999 Jan 15;365(1):9-25 PMID: 9988118
  8. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia.
    Brain Pathol. 2000 Jan;10(1):95-112 PMID: 10668900
  9. Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.
    J Cereb Blood Flow Metab. 1990 Sep;10(5):646-53 PMID: 2384538
  10. Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid.
    Neurosci Lett. 2000 Jan 7;278(1-2):101-4 PMID: 10643811
  11. Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression.
    Stroke. 1998 Sep;29(9):1937-50; discussion 1950-1 PMID: 9731622
  12. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes.
    J Neurochem. 2000 Aug;75(2):812-8 PMID: 10899959
  13. Zinc and brain injury.
    Annu Rev Neurosci. 1998;21:347-75 PMID: 9530500
  14. Pathobiology of ischaemic stroke: an integrated view.
    Trends Neurosci. 1999 Sep;22(9):391-7 PMID: 10441299
  15. Extracellular neurotransmitter changes in cerebral ischaemia.
    Cerebrovasc Brain Metab Rev. 1995 Spring;7(1):1-54 PMID: 7742171
  16. Ischemic tolerance in the brain.
    Neurology. 1997 Feb;48(2):306-11 PMID: 9040711
  17. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
    Stroke. 1998 Jan;29(1):152-8 PMID: 9445345
  18. Respiratory chain inhibition induces tolerance to focal cerebral ischemia.
    J Cereb Blood Flow Metab. 1999 Nov;19(11):1229-37 PMID: 10566969
  19. N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
    Ann Neurol. 1989 Apr;25(4):398-403 PMID: 2565699
  20. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia.
    Brain Res. 1996 Apr 29;718(1-2):233-6 PMID: 8773794
  21. Enzymatic function of nitric oxide synthases.
    Cardiovasc Res. 1999 Aug 15;43(3):521-31 PMID: 10690324
  22. Sublethal in vitro glucose-oxygen deprivation protects cultured hippocampal neurons against a subsequent severe insult.
    Neuroreport. 1998 May 11;9(7):1273-6 PMID: 9631411
  23. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.
    Nature. 1997 Dec 11;390(6660):622-5 PMID: 9403693
  24. Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats.
    Acta Physiol Scand. 1994 Nov;152(3):349-50 PMID: 7872013
  25. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat.
    Neurosci Lett. 1990 Feb 16;109(3):247-52 PMID: 2330128
  26. Gene expression induced by cerebral ischemia: an apoptotic perspective.
    J Cereb Blood Flow Metab. 1997 Aug;17(8):815-32 PMID: 9290580
  27. Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?
    Cerebrovasc Brain Metab Rev. 1990 Spring;2(1):1-26 PMID: 2144995
  28. Neurotrophin-mediated potentiation of neuronal injury.
    Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):276-84 PMID: 10383120
  29. Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones.
    J Physiol. 2000 Oct 1;528 Pt 1:39-52 PMID: 11018104
  30. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis?
    J Cereb Blood Flow Metab. 1996 Mar;16(2):195-201 PMID: 8594050
  31. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.
    Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12866-9 PMID: 10536014
  32. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate.
    J Neurosci. 1995 Oct;15(10):6377-88 PMID: 7472402
  33. Glutamate neurotoxicity and diseases of the nervous system.
    Neuron. 1988 Oct;1(8):623-34 PMID: 2908446
  34. Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats.
    Brain Res. 1998 Jan 26;782(1-2):290-6 PMID: 9519275
  35. A phospholipase C inhibitor ameliorates postischemic neuronal damage in rats.
    Stroke. 1992 Aug;23(8):1163-6 PMID: 1636192
  36. Neurobiology of zinc and zinc-containing neurons.
    Int Rev Neurobiol. 1989;31:145-238 PMID: 2689380
  37. The changing landscape of ischaemic brain injury mechanisms.
    Nature. 1999 Jun 24;399(6738 Suppl):A7-14 PMID: 10392575
  38. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
    Nature. 1997 Oct 23;389(6653):865-70 PMID: 9349820
  39. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.
    Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):436-41 PMID: 10618436
  40. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion.
    Trends Pharmacol Sci. 1998 Jul;19(7):287-98 PMID: 9703762
  41. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals.
    Neuroscience. 1999 Mar;89(1):175-82 PMID: 10051227
  42. Caspases as treatment targets in stroke and neurodegenerative diseases.
    Ann Neurol. 1999 Apr;45(4):421-9 PMID: 10211465
  43. 'Ischemic tolerance' phenomenon found in the brain.
    Brain Res. 1990 Sep 24;528(1):21-4 PMID: 2245337
  44. Nitric oxide synthase in models of focal ischemia.
    Stroke. 1997 Jun;28(6):1283-8 PMID: 9183363
  45. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
    Circulation. 1986 Nov;74(5):1124-36 PMID: 3769170
  46. Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats.
    J Cereb Blood Flow Metab. 1998 Oct;18(10):1107-13 PMID: 9778187
  47. A syndrome of acute zinc loss. Cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction.
    Arch Neurol. 1975 Nov;32(11):745-51 PMID: 1180744
  48. Characterization of cysteinyl-leukotriene formation in primary astroglial cell cultures.
    J Pharm Pharmacol. 1990 Mar;42(3):191-3 PMID: 1974615
  49. Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors.
    J Neurosci. 1999 Mar 1;19(5):1657-62 PMID: 10024352
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI11003
Published
2000-09-00
Pages
723-31
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC381398
Subset
IM
Grants
NINDS NIH HHS · F32 NS010926 · United States
NINDS NIH HHS · P01 NS032636 · United States
NINDS NIH HHS · 1F32NS10926-01 · United States
NINDS NIH HHS · NS32636 · United States
External Links
PubMed source DOI: 10.1172/JCI11003 PMC Full Text View journal details
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