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PMID: 1100764 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.

The Journal of experimental medicine ·Vol. 142 ·No. 3 ·1975-09-01 ·Pages 694-700

Taussig MJ, Munro AJ, Campbell R, David CS, Staines NA

Abstract

Further mapping of the mouse T-cell factor specific for poly(Try,Glu)-polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.

MeSH Terms

Animals Antibody Formation Antigens Bone Marrow Cells Bone Marrow Transplantation Chromosome Mapping Crosses, Genetic Female Genes Histocompatibility Antigens Lymph Nodes/transplantation Male Mice Peptides/immunology Skin Transplantation Spleen/transplantation T-Lymphocytes/immunology Thymus Gland/transplantation Time Factors Transplantation, Homologous

Chemicals

Antigens Histocompatibility Antigens Peptides

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Taussig M J

Munro A J

Campbell R

David C S

Staines N A

References (6)

6 references, click to expand

Antigen design and immune response.
Harvey Lect. 1973;67:213-46 PMID: 4122974
The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.
Adv Immunol. 1975;20:125-95 PMID: 47219
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.
J Exp Med. 1975 Jan 1;141(1):263-8 PMID: 1090698
T cell factor which can replace T cells in vivo.
Nature. 1974 Mar 15;248(445):234-6 PMID: 4594643
Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell defects in SJL mice.
J Exp Med. 1975 Mar 1;141(3):703-7 PMID: 46918
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.
J Exp Med. 1974 Dec 1;140(6):1579-87 PMID: 4610078

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.142.3.694

Published

1975-09-01

Pages

694-700

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2189912

Subset

External Links

PubMed source DOI: 10.1084/jem.142.3.694 PMC Full Text View journal details

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Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.

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