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PMID: 11008108 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The role of immune responses in bone loss during periodontal disease.

Microbes and infection ·Vol. 2 ·No. 10 ·2000-08-00 ·Pages 1181-92

Baker PJ

Abstract

A network of cytokines and other soluble mediators unites the immune system and bone; bacterial infections induce immune responses which may perturb this network. Periodontal diseases are Gram-negative infections resulting in bone loss in the jaw. Evidence is presented that immune responses to these infections produces net resorption of bone.

MeSH Terms
Alveolar Bone Loss/immunology,microbiology,pathology Bone Remodeling Cytokines/metabolism Gram-Negative Bacteria/immunology,metabolism Gram-Negative Bacterial Infections/complications,immunology,pathology Humans
Chemicals
Cytokines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Baker P J
Biology Department, Bates College, Lewistown, Maine 04240, USA.
Article Info
Journal
Microbes and infection
Abbr.
Microbes Infect
ISSN
1286-4579
DOI
10.1016/s1286-4579(00)01272-7
Published
2000-08-00
Pages
1181-92
Language
English
Region
France
NLM ID
100883508
Subset
IM
Grants
NIAID NIH HHS · R01 AI24544 · United States
NIDCR NIH HHS · R29 DE10728 · United States
External Links
PubMed source DOI: 10.1016/s1286-4579(00)01272-7 View journal details
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