Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants.

Molecular & general genetics : MGG ·Vol. 139 ·No. 2 ·1975-08-05 ·Pages 121-32

Masselot M, De Robichon-Szulmajster H

Abstract

In order to analyse how many structural genes are implicated in the specific steps of the biosynthesis of methionine in Sacch. cerevisiae, a hundred mutants were studied by complementation. 21 groups were defined named MET1 to MET25. Neither recombination between independent mutants of the same complementation group nor linkage between different groups was found. Preliminary to biochemical studies, mutants of each complementation group were tested for their capacity to utilize various precursors of methionine.

MeSH Terms

Genes Genetic Linkage Genetics, Microbial Methionine/biosynthesis Mutation Recombination, Genetic Saccharomyces cerevisiae/metabolism

Chemicals

Methionine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Masselot M

De Robichon-Szulmajster H

References (8)

8 references, click to expand

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Genetic Mapping in Saccharomyces IV. Mapping of Temperature-Sensitive Genes and Use of Disomic Strains in Localizing Genes.
Genetics. 1973 May;74(1):33-54 PMID: 17248609
Nonsense mutation in the regulatory gene ETH2 involved in methionine biosynthesis in Saccharomyces cervisiae.
Genetics. 1972 Aug;71(4):535-50 PMID: 4560067
Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.
J Bacteriol. 1969 Jan;97(1):328-36 PMID: 5764336
Methionine-mediated repression in Saccharomyces cerevisiae: a pleiotropic regulatory system involving methionyl transfer ribonucleic acid and the product of gene eth2.
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Methionine biosynthesis in yeast.
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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00264692

Published

1975-08-05

Pages

121-32

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00264692

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Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants.

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