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PMID: 1103369 Published · ppublish English Journal Article

Gastric inhibitory polypeptide: effect on glucose-induced insulin release from isolated rat pancreatic islets in vitro.

Diabetologia ·Vol. 11 ·No. 5 ·1975-10-00 ·Pages 483-4

Schauder P, Brown JC, Frerichs H, Creutzfeldt W

Abstract

Gastric Inhibitory Polypeptide (GIP; 1 or 10 mug/ml) potentiated glucose-induced (8 or 16.6 mM) insulin (IRI) release from isolated rat pancreatic islets. Basal release was unaffected. The threshold concentration of glucose necessary for GIP to modulate IRI release was between 6 and 8 mM. GIP had no effect on IRI release from islets submitted to a maximal glucose stimulus (25 mM).

MeSH Terms
Animals Gastrointestinal Hormones/pharmacology Glucose/pharmacology In Vitro Techniques Insulin/metabolism Insulin Secretion Islets of Langerhans/drug effects,metabolism Male Peptides/pharmacology Rats Stimulation, Chemical
Chemicals
Gastrointestinal Hormones Insulin Peptides Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schauder P
Brown J C
Frerichs H
Creutzfeldt W
References (14)
14 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00429919
Published
1975-10-00
Pages
483-4
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00429919 View journal details
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