Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice.
In the present studies we have confirmed that the random copolymer of L-glutamic acid50-L-tyrosine50 (GT) fails to induce an antibody response in a large number of inbred strains of mice. Nevertheless, GT complexed to methylated bovine serum albumin (MBSA) elicits a GT-specific IgG PFC response in vivo. Furthermore, injection of BALB/c mice with 10 to 100 mug of GT specifically decreases their ability to develop anti-GT PFC responses to a subsequent challenge with GT-MBSA. GT-specific tolerance can be transferred to normal, syngeneic recipients by spleen cells or thymocytes of GT-primed animals. These results indicate that the stimulation of suppressor cells can be observed in nonresponder mice with another synthetic polypeptide besides GAT. Various parameters of GT-specific immunosuppression in BALB/c mice are described. The application of these techniques to the study of the genetic factors controlling the stimulation of specific immune suppression is discussed.
11 references, click to expand
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Fractionation of nucleic acids with the methylated albumin column.J Mol Biol. 1962 Mar;4:161-72 PMID: 13918158
-
Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.J Exp Med. 1973 Nov 1;138(5):1107-20 PMID: 4126766
-
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).J Exp Med. 1974 Sep 1;140(3):648-59 PMID: 4137682
-
Histocompatibility-linked immune response genes.Science. 1972 Jan 21;175(4019):273-9 PMID: 4109878
-
A cellular basis for genetically controlled immunologic unresponsiveness in mice: tolerance induction in T-cells.Proc Natl Acad Sci U S A. 1973 Jan;70(1):250-4 PMID: 4539650
-
Genetic control of immune responses in vitro. 3. Tolerogenic properties of the terpolymer L-glutamic acid 60-L-alanine30-L-tyrosine10 (GAT) for spleen cells from nonresponder (H-2s and H-2q) mice.J Exp Med. 1974 Jul 1;140(1):172-84 PMID: 4857865
-
Mapping the H-2-linked genes governing, respectively, the immune responses to a glutamic acid-alanine-tyrosine copolymer and to limiting doses of ovalbumin.J Immunol. 1973 Dec;111(6):1621-5 PMID: 4750862
-
Genetic control of specific immune responses.Adv Immunol. 1969;11:31-74 PMID: 4908392
-
Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes.J Exp Med. 1971 Aug 1;134(2):395-416 PMID: 4934502
-
Specific immune response genes of the guinea pig. I. Dominant genetic control of immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine.J Exp Med. 1971 Aug 1;134(2):458-70 PMID: 5559610
-
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.J Exp Med. 1966 May 1;123(5):859-79 PMID: 5938816
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