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PMID: 11048729 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Corpse clearance defines the meaning of cell death.

Nature ·Vol. 407 ·No. 6805 ·2000-10-12 ·Pages 784-8

Savill J, Fadok V

Abstract

While philosophers seek the meaning of life, cell biologists are becoming ever more interested in the meaning of death. Apoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes. Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues.

MeSH Terms
Animals Apoptosis Forecasting Humans Immunity/physiology Inflammation Macrophages/physiology Membrane Lipids/physiology Phagocytes/physiology Phagocytosis
Chemicals
Membrane Lipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Savill J
University of Edinburgh/Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK. [email protected]
Fadok V
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
2000-10-12
Pages
784-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
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