Exocrine pancreas: evidence for topographic partition of secretory function.

Science (New York, N.Y.) ·Vol. 190 ·No. 4216 ·1975-11-21 ·Pages 795-7

Malaisse-Lagae F, Ravazzola M, Robberecht P, Vandermeers A, Malaisse WJ, Orci L

Abstract

The pattern of amylase, lipase, and chymotrpsinogen content found in pancreatic exocrine tissue surrounding the islets of Langerhans (periinsular halos) differs from that of the rest, or teleinsular part, of the pancreas. Such a topographic partition of secretory function may play a role in the regulation of pancreatic juice composition.

MeSH Terms

Amylases/metabolism Animals Chymotrypsinogen/metabolism Diabetes Mellitus/physiopathology Islets of Langerhans/cytology,physiology Lipase/metabolism Mice Pancreas/cytology,physiology,physiopathology Pancreatic Juice/metabolism Rats

Chemicals

Chymotrypsinogen Lipase Amylases

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Malaisse-Lagae F

Ravazzola M

Robberecht P

Vandermeers A

Malaisse W J

Orci L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1105788

Published

1975-11-21

Pages

795-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1105788 View journal details

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