Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

Adenocarcinoma/genetics,metabolism Animals Breast Neoplasms/genetics,metabolism COS Cells Carrier Proteins/genetics Cell Cycle Proteins/genetics,isolation & purification,physiology Cell Transformation, Neoplastic/genetics Cells, Cultured Cellular Senescence/genetics Chromosomes, Human, Pair 17/genetics Cyclin-Dependent Kinase Inhibitor p16 DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor Female Fibroblasts/cytology,metabolism Gene Amplification Gene Deletion Gene Expression Regulation, Neoplastic Genes, BRCA1 Humans Mice Neoplasm Proteins/biosynthesis,genetics,isolation & purification,physiology Neoplastic Syndromes, Hereditary/genetics Nuclear Proteins/genetics Oncogenes Polycomb Repressive Complex 1 Promoter Regions, Genetic Protein Biosynthesis Proteins/genetics Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-myc/antagonists & inhibitors Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors Repressor Proteins/genetics,isolation & purification,physiology Retinoblastoma-Binding Protein 1 T-Box Domain Proteins/genetics,isolation & purification,physiology Transcription Factor DP1 Transcription Factors/antagonists & inhibitors Transfection Tumor Cells, Cultured Tumor Suppressor Protein p14ARF

Arid4a protein, mouse BMI1 protein, human Bmi1 protein, mouse Carrier Proteins Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p16 DNA-Binding Proteins E2F Transcription Factors E2F1 Transcription Factor E2F1 protein, human E2f1 protein, mouse Neoplasm Proteins Nuclear Proteins Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-myc Repressor Proteins Retinoblastoma-Binding Protein 1 T-Box Domain Protein 2 T-Box Domain Proteins Transcription Factor DP1 Transcription Factors Tumor Suppressor Protein p14ARF Polycomb Repressive Complex 1 HRAS protein, human Proto-Oncogene Proteins p21(ras)