Regulation of the meiotic cell cycle in oocytes.

Current opinion in cell biology ·Vol. 12 ·No. 6 ·2000-12-00 ·Pages 666-75

Nebreda AR, Ferby I

Abstract

The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the signalling mechanisms that induce G2-arrested oocytes to resume and complete the meiotic cell cycle.

MeSH Terms

Animals CDC2 Protein Kinase/metabolism Cell Cycle/physiology Cell Cycle Proteins/metabolism Cyclin B/metabolism Cyclins/metabolism G2 Phase/physiology MAP Kinase Signaling System/physiology Meiosis/physiology Mitosis/physiology Oocytes/cytology,metabolism Protein Serine-Threonine Kinases/metabolism Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins c-mos/metabolism S Phase/physiology Xenopus Xenopus Proteins

Chemicals

CKS2 protein, Xenopus Cell Cycle Proteins Cyclin B Cyclins Xenopus Proteins ls27 protein, Xenopus MYT1 kinase, Xenopus Protein-Tyrosine Kinases Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-mos CDC2 Protein Kinase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nebreda A R

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany. [email protected]

Ferby I

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(00)00150-2

[email protected]

Published

2000-12-00

Pages

666-75

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(00)00150-2 View journal details

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Regulation of the meiotic cell cycle in oocytes.

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