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PMID: 1107328 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Adaptation of membrane lipids to alcohols.

Journal of bacteriology ·Vol. 125 ·No. 2 ·1976-02-00 ·Pages 670-8

Ingram LO

Abstract

The effects of alcohols of different chain lengths on the fatty acid composition of Escherichia coli K-12 have been examined. My results indicate that these cells radically change their fatty acid composition when grown in the presence of alcohols. These changes represent an adaptive membrane alteration compensating for the direct physicochemical interaction of alcohols with the membrane. Similar adaptive responses of membrane lipids are proposed as a possible biochemical basis for tolerance to alcohol and related drugs.

MeSH Terms
Acetaldehyde/pharmacology Acetates/pharmacology Adaptation, Biological Alcohols/pharmacology Cell Membrane/metabolism Drug Antagonism Drug Synergism Escherichia coli/metabolism Ethanol/pharmacology Fatty Acids/biosynthesis Lipids/biosynthesis Models, Biological Palmitic Acids/pharmacology Phospholipids/biosynthesis
Chemicals
Acetates Alcohols Fatty Acids Lipids Palmitic Acids Phospholipids Ethanol Acetaldehyde
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ingram L O
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.125.2.670-678.1976
Published
1976-02-00
Pages
670-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC236128
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.125.2.670-678.1976 PMC Full Text View journal details
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